Impact of concomitant antacid administration on gabapentin plasma exposure and oral bioavailability in healthy adult subjects.
Summary of "Impact of concomitant antacid administration on gabapentin plasma exposure and oral bioavailability in healthy adult subjects."
The aim of this open-label, randomized, and 3-period crossover study was to evaluate the influences of concomitant antacid administration on the plasma disposition, intestinal absorption, and urinary excretion of gabapentin in humans. Gabapentin (200 mg) was orally administered alone, with 1 g magnesium oxide (MgO), or with 20 mg omeprazole to 13 healthy adult subjects. Oral bioavailability (BA) of gabapentin was estimated by 24-hour urine collection. The C(max), T(max) and AUC(0-∞) of gabapentin + MgO were significantly lower than that of gabapentin alone (by 33%, 36% and 43%, respectively) and gabapentin + omeprazole (by 29%, 46% and 40%, respectively), respectively. In contrast, no significant differences were observed in the plasma disposition parameters of gabapentin between the alone and omeprazole treatments. The gabapentin BA in the MgO treatment was significantly lower, by 32% and 39%, compared to the alone and omeprazole treatments, respectively. There was no significant difference in the gabapentin BA between the alone and omeprazole treatments. Concomitant MgO and omeprazole did not affect the renal clearance of gabapentin. In conclusion, concomitant MgO decreased the gabapentin exposure through the reduction of intestinal absorption extent and rate. This reduction may be independent of the suppression of gastrointestinal acidification caused by antacids.
Affiliation
Department of Hospital Pharmacy, Hamamatsu University School of Medicine.
Journal Details
This article was published in the following journal.
Name: Drug metabolism and pharmacokinetics
ISSN: 1880-0920
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22240839
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Administration, Oral
The giving of drugs, chemicals, or other substances by mouth.
Capsules
Hard or soft soluble containers used for the oral administration of medicine.
Photochemotherapy
Therapy using oral or topical photosensitizing agents with subsequent exposure to light.
Arsenic Poisoning
Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)
Self Administration
Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal.
PubMed Articles
Thermal antinociceptive effect of orally administered gabapentin in healthy cats.
Objective-To determine the thermal antinociceptive effect of various single doses of gabapentin administered orally in cats. Animals-6 healthy adult domestic shorthair cats. Procedures-Baseline skin t...
Dried plasma spots were employed as an alternative sample collection technique for the quantitative determination of gabapentin in human plasma, using an automated liquid chromatography tandem mass sp...
PURPOSE: Systemic exposure to niflumic acid was significantly increased when talniflumate was given orally together with a meal. To clarify the underlying mechanism, an in vitro dissolution study of t...
Chinese Holstein, bred by mating the Holstein-Friesian to Chinese Yellow Cattle, is a major dairy cattle breed in China. Eprinomectin is widely used in the treatment of nematode and ectoparasite infec...
Objective-To compare pharmacokinetics after IV, IM, and oral administration of a single dose of meloxicam to Hispaniolan Amazon parrots (Amazona ventralis). Animals-11 healthy parrots. Procedures-Coho...
Clinical Trials
Plasma Gabapentin Concentration During and Following Cardiac Bypass
This open label investigation is to determine whether cardiopulmonary bypass affects plasma gabapentin concentration after preoperative administration in the setting of cardiac bypass surg...
A Limited Food Effect Study of Gabapentin 800 mg Tablets
The purpose of this study is to compare the relative bioavailability of 800 mg Gabapentin Tablets by Purepac Pharmaceutical Co. with that of 400 mg (2 x 400 mg) NEURONTIN® by Parke-Davis...
The purpose of this study is to determine the effectiveness of an oral medication called gabapentin in reducing pain after Photorefractive Keratectomy (PRK) eye surgery and to assess the f...
The Effect of Gabapentin on the Sensation and Impact of Tinnitus
This study evaluated the effectiveness of gabapentin in treating tinnitus in two populations: Tinnitus with associated acoustic trauma and tinnitus without associated acoustic trauma. The...
A Relative Bioavailability Study of Gabapentin 400 mg Capsules Under Non-Fasting Conditions
To compare the relative bioavailability of gabapentin 400 mg capsules (Purepac) with that of NEURONTIN® 400 mg capsules (Parke-Davis) in healthy adult male subjects under non-fasting cond...
