Physicochemical studies of pyridinium gemini surfactants with promethazine hydrochloride in aqueous solution.
Summary of "Physicochemical studies of pyridinium gemini surfactants with promethazine hydrochloride in aqueous solution."
The mixed micellization and interfacial behavior of pyridinium gemini surfactants, 1,1'-(1,1'-(ethane-1,2-diylbis-(sulfanediyl))bis(alkane-2,1-diyl))dipyridinium bromide, i.e., [12-(S-2-S)-12], [14-(S-2-S)-14], [16-(S-2-S)-16] with a phenothiazine tranquilizer drug, promethazine hydrochloride (PMT), has been investigated by conductivity, surface tension and steady state fluorescence measurements. Different spectroscopic techniques like fluorescence, UV-visible and NMR were also employed to understand the nature of interactions between the pyridinium gemini surfactants and PMT. The various micellar, interfacial and associated thermodynamic parameters for different mole fractions of PMT-pyridinium gemini surfactant mixtures have been evaluated. Synergism was observed in the mixed micelle as well as the monolayer formed by these mixtures. The fluorescence quenching experiment indicates that the interactions between PMT and surfactants are hydrophobic in nature. The UV-visible measurements reveal the distinct formation of a drug-surfactant complex. The detailed mechanism for the type of interactions was further studied by NMR titrations which show cation-π interactions between PMT and pyridinium gemini surfactant molecules.
Affiliation
Department of Chemistry, UGC-Centre for Advanced Studies, Guru Nanak Dev University, Amritsar-143005, India. rakesh_chem@yahoo.com.
Journal Details
This article was published in the following journal.
Name: Physical chemistry chemical physics : PCCP
ISSN: 1463-9084
Pages: 887-98
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22119804
- DOI: http://dx.doi.org/10.1039/c1cp22448d
Medical and Biotech [MESH] Definitions
Isodesmosine
2-(4-Amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinium. A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring.
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Studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. The common types of analytic study are CASE-CONTROL STUDIES; COHORT STUDIES; and CROSS-SECTIONAL STUDIES.
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Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Promethazine
A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
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