Impact of a region wide antimicrobial stewardship guideline on urinary tract infection prescription patterns.
Summary of "Impact of a region wide antimicrobial stewardship guideline on urinary tract infection prescription patterns."
Background Fluoroquinolones are frequently prescribed for non complicated urinary tract infection treatments and have a negative ecological impact. We aimed to substitute them by antibiotics with narrower activity spectrum in order to preserve fluoroquinolone activity in complicated hospital infections. Objective To assess the impact of a multi-modal approach that combines the dispatching of antibiotic prescription guidelines and voluntary attendance at educational sessions on general practitioners' (GP) antibiotic prescription habits. Setting This study was led in Franche-Comté, a French eastern region, where GPs were given a guideline recommending a restricted use of fluoroquinolones for urinary tract infections. Method Segmented regression analysis of interrupted time series was used to assess changes in antibiotic prescription. Main outcome measure: The antibiotic prescription data of nitrofurantoin, fosfomycin-trometamol and fluoroquinolones for women aged 15-65 years were obtained from the regional agency of health insurance. Results Twenty months after intervention, the number of nitrofurantoin and fosfomycintrometamol prescriptions increased by 36.8% (95%
CI:
30.6-42.2) and 28.5% (95%
CI:
22.9-35.4), respectively, while that of norfloxacin decreased by 9.1% (95%
CI:
-15.3 to -3.5). Conclusion This study suggests that the dispatch of the guideline on urinary tract infection had a moderate impact on antibiotic prescriptions.
Affiliation
Service d'Hygiène Hospitalière, Centre Hospitalier Universitaire Besançon, 3 Bd Fleming, 25030, Besancon, Cedex, France.
Journal Details
This article was published in the following journal.
Name: International journal of clinical pharmacy
ISSN: 2210-7711
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22252772
- DOI: http://dx.doi.org/10.1007/s11096-012-9606-6
Medical and Biotech [MESH] Definitions
Sulfachlorpyridazine
A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.
Oxolinic Acid
Synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
Urology
A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.
Cinoxacin
Synthetic antimicrobial related to OXOLINIC ACID and NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
Urinary Tract Physiological Phenomena
Properties, functions, and processes of the URINARY TRACT as a whole or of any of its parts.
PubMed Articles
Antimicrobial resistance is increasing; however, antimicrobial drug development is slowing. Now more than ever before, antimicrobial stewardship is of the utmost importance as a way to optimize the us...
Prescribing trends before and after implementation of an antimicrobial stewardship program.
Antimicrobial stewardship programs are recommended to reduce antimicrobial resistance by reducing inappropriate use of antimicrobials. We implemented an antimicrobial stewardship program and aimed to...
Benign prostatic hyperplasia and lower urinary tract symptoms.
To the Editor: In their Clinical Practice article (July 19 issue)(1) reviewing therapeutic options for the management of lower urinary tract symptoms, Sarma and Wei refer to European Association of Ur...
Benign prostatic hyperplasia and lower urinary tract symptoms.
To the Editor: In their Clinical Practice article (July 19 issue)(1) reviewing therapeutic options for the management of lower urinary tract symptoms, Sarma and Wei refer to European Association of Ur...
The antibacterial shield of the human urinary tract.
Antibacterial peptides and proteins maintain the sterility of the human urinary tract. A broad-spectrum antimicrobial protein, ribonuclease 7 (RNase 7), previously discovered to play a role in control...
Clinical Trials
The information collected will optimize the management of patients with urinary tract infections with secondary bacteremia, primarily with gram negative bacteria especially Escherichia co...
The Causes and Interpretation of Low-level Resistance in Staphylococcus Aureus
The hypothesis of this investigation is that rate of isolation of resistant nosocomial pathogens can be explained by a combination of measures that include, among other things, antimicrobi...
Decreasing Catheter-Associated Urinary Tract Infections in the Pediatric Intensive Care Unit
The purpose of this study is to identify risk factors associated with indwelling urinary catheters, as well as to assess the nurses' knowledge and adherence to hospital policies. The study...
Antimicrobial Drug Use and Resistant Staphylococcus Aureus
The purpose of this investigation is to study the relationships between antimicrobial stewardship program efforts, antimicrobial drug use, and infection control efforts to the incidence r...
Lower Urinary Tract Infection (UTI) Evaluation in Women With Uterine Leiomyomata
To the investigators knowledge there is no research data published to date regarding the lower urinary tract symptoms in women with leiomyomas. The primary aims of this study are: 1. T...
