Preparation of highly purified monomeric human serum albumin as secondary reference material for standardization of urinary albumin immunoassays.
Summary of "Preparation of highly purified monomeric human serum albumin as secondary reference material for standardization of urinary albumin immunoassays."
International external quality assessments have shown variation in results of urinary albumin among various immunoassays. A well-defined candidate reference material for urine albumin (cRM-UA) was prepared to improve standardization.
Affiliation
Department of Laboratory Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan. yoshiito@asahikawa-med.ac.jp
Journal Details
This article was published in the following journal.
Name: Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Pages: 175-81
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21963465
- DOI: http://dx.doi.org/10.1016/j.cca.2011.09.016
Medical and Biotech [MESH] Definitions
Hypoalbuminemia
A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).
Serum Albumin, Radio-iodinated
Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)
Serum Globulins
All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)
Serum Albumin, Bovine
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
Prealbumin
A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease.
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