Track topics on Twitter Track topics that are important to you
Permethrin is a common synthetic chemical, widely used as an insecticide in agriculture and other domestic applications. The previous reports indicated that permethrin is a highly toxic synthetic pyrethroid pesticide to human and environmental health. Therefore, the present experiment was undertaken to determine the effectiveness of olive leaf extract in modulating the permethrin induced genotoxic and oxidative damage in rats. The animals used were broadly divided into four (A, B, C and D) experimental groups. Group A rats served as control animals and received distilled water intraperitoneally (n = 5). Groups B and C rats received intraperitoneal injections of permethrin (60 mg kg(-1) b.w) and olive leaf extract (500 mg kg(-1) b.w), respectively. Group D rats received permethrin (60 mg kg(-1) b.w) plus olive leaf extract (500 mg kg(-1) b.w). Rats were orally administered their respective feed daily for 21 days. At the end of the experiment rats were anesthetized and serum and bone marrow cell samples were obtained. Genotoxic damage was assessed by micronucleus and chromosomal aberration assays. Total antioxidant capacity and total oxidant status were also measured in serum samples to assess oxidative status. Treatment of Group B with permethrin resulted in genotoxic damage and increased total oxidant status levels. Permethrin treatment also significantly decreased (P < 0.05) total antioxidant capacity level when compared to Group A rats. Group C rats showed significant increases (P < 0.05) in total antioxidant capacity level and no alterations in cytogenetic parameters. Moreover, simultaneous treatments with olive leaf extract significantly modulated the toxic effects of permethrin in Group D rats. It can be concluded that olive leaf extract has beneficial influences and could be able to antagonize permethrin toxicity. As a result, this investigation clearly revealed the protective role of olive leaf extract against the genetic and oxidative damage by permethrin in vivo for the first time.
Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey.
This article was published in the following journal.
Phenolic compounds (PC) of virgin olive oil exert several biochemical and pharmacological beneficial effects. Some dietary PC seem to prevent/improve obesity and metabolic-related disorders such as no...
The leaves of Moringa oleifera Lam possess some potential medicinal value. The aim of this study was to evaluate the protective effect of M. oleifera leaf powder and its extract against hyperlipidemia...
Solanum trilobatum Linn is a medicinal plants used in India from many centuries to cure various diseases. The purpose of the study is to evaluate the ameliorative potential of the ethanolic leaf extra...
Oxidative stress is associated with most components and complications of Metabolic Syndrome (MetS). Artichoke Leaf Extract (ALE) has demonstrated anti-oxidant properties in both laboratory and animal ...
Obesity is associated with a low-grade inflammatory status that affects vascular function. Previous studies have reported the beneficial effects of Psidium guajava L. (guava) on diabetes. Here we eval...
Mulberry leaf teas or extracts are used as a natural remedy for diabetes in some countries. Animal studies have shown some effect of mulberry leaf extract on blood glucose. The purpose of ...
The purpose of this study is to determine whether the intake of a daily dosage of standardized olive extract provides any protection against bone loss.
The investigators performed a 8-week, randomized, double-blind, placebo-controlled crossover human trial to evaluate the efficacy and safety of persimmon leaf extract on blood glucose. The...
Six weeks of supplementation of an olive extract will: - Improve antioxidant status - Reduce inflammation - Reduce muscle damage - Improve exercise performance ...
The trial is to test the resolution of pain, swelling and other signs of periapical infection and the antimicrobial efficacy when using the neem leaf extract compared to chlorhexidine as r...
Oil extracted from fruit of the OLIVE TREE (genus Olea).
A plant genus of the family OLEACEAE. The olive fruit is the source of olive oil.
A dehydrated extract of thyroid glands. After the removal of fat and connective tissue, the extract is dried or lyophilized to yield a yellowish to buff-colored amorphous powder containing 0.17-0.23% of iodine.
A pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory GAMMA-AMINOBUTYRIC ACID subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...
Osteoporosis is a disease in which the bones become extremely porous, are subject to fracture, and heal slowly, occurring especially in women following menopause and often leading to curvature of the spine from vertebral collapse. Follow and track&n...