Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the han chinese population.
Summary of "Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the han chinese population."
Homocysteine is known to be an independent risk factor for congenital heart disease (CHD). Methionine synthase reductase (MTRR) is essential for the adequate remethylation of homocysteine, which is the dominant pathway for homocysteine removal during early embryonic development.
Affiliation
236 HuanJing Bldg, School of Life Sciences, Fudan University, 220 Handan Rd, Shanghai 200433, China or Bin Qiao, BS, Institute of Cardiovascular Disease, General Hospital of Jinan Military Region, 8 Lashan Rd., Jinan 250022, China. wanghy@fudan.edu.cn o
Journal Details
This article was published in the following journal.
Name: Circulation
ISSN: 1524-4539
Pages: 482-90
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22179537
- DOI: http://dx.doi.org/10.1161/CIRCULATIONAHA.111.050245
Medical and Biotech [MESH] Definitions
D-ala(2),mephe(4),met(0)-ol-enkephalin
A stable synthetic analog of methionine enkephalin (ENKEPHALIN, METHIONINE). Actions are similar to those of methionine enkephalin. Its effects can be reversed by narcotic antagonists such as naloxone.
Sulfite Reductase (ferredoxin)
A FERREDOXIN-dependent oxidoreductase that is primarily found in PLANTS where it plays an important role in the assimilation of SULFUR atoms for the production of CYSTEINE and METHIONINE.
Methionine Sulfoxide Reductases
Reductases that catalyze the reaction of peptide-L-methionine -S-oxide + thioredoxin to produce peptide-L-methionine + thioredoxin disulfide + H(2)O.
Methionine Adenosyltransferase
An enzyme that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP. EC 2.5.1.6.
Methionine-trna Ligase
An enzyme that activates methionine with its specific transfer RNA. EC 6.1.1.10.
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