Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity.
Summary of "Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity."
The aim of this study was to investigate the differential responses of the primary auditory cortex to auditory stimuli in autistic spectrum disorder with or without auditory hypersensitivity. Auditory-evoked field values were obtained from 18 boys (nine with and nine without auditory hypersensitivity) with autistic spectrum disorder and 12 age-matched controls. Autistic disorder with hypersensitivity showed significantly more delayed M50/M100 peak latencies than autistic disorder without hypersensitivity or the control. M50 dipole moments in the hypersensitivity group were statistically larger than those in the other two groups. M50/M100 peak latencies were correlated with the severity of auditory hypersensitivity; furthermore, severe hypersensitivity induced more behavioral problems. This study indicates auditory hypersensitivity in autistic spectrum disorder as a characteristic response of the primary auditory cortex, possibly resulting from neurological immaturity or functional abnormalities in it.
Affiliation
aUnited Graduate School of Child Development bDepartment of Neurosurgery cDivision of Function Diagnostic Sciences dDepartment of Molecular Research Center for Children's Mental Development, Osaka University Graduate School of Medicine, Osaka, Japan.
Journal Details
This article was published in the following journal.
Name: Neuroreport
ISSN: 1473-558X
Pages: 113-8
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22146579
- DOI: http://dx.doi.org/10.1097/WNR.0b013e32834ebf44
Medical and Biotech [MESH] Definitions
Hair Cells, Auditory, Outer
Sensory cells of organ of Corti. In mammals, they are usually arranged in three or four rows, and away from the core of spongy bone (the modiolus), lateral to the INNER AUDITORY HAIR CELLS and other supporting structures. Their cell bodies and stereocilia increase in length from the cochlear base toward the apex and laterally across the rows, allowing differential responses to various frequencies of sound.
Hearing Loss, Central
Hearing loss due to disease of the AUDITORY PATHWAYS (in the CENTRAL NERVOUS SYSTEM) which originate in the COCHLEAR NUCLEI of the PONS and then ascend bilaterally to the MIDBRAIN, the THALAMUS, and then the AUDITORY CORTEX in the TEMPORAL LOBE. Bilateral lesions of the auditory pathways are usually required to cause central hearing loss. Cortical deafness refers to loss of hearing due to bilateral auditory cortex lesions. Unilateral BRAIN STEM lesions involving the cochlear nuclei may result in unilateral hearing loss.
Geniculate Bodies
Part of the diencephalon inferior to the caudal end of the dorsal thalamus. Includes the lateral geniculate body which relays visual impulses from the optic tract to the calcarine cortex, and the medial geniculate body which relays auditory impulses from the lateral lemniscus to the auditory cortex.
Autistic Disorder
A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-IV)
Evoked Potentials, Auditory
The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS.
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