Homogeneity study of ointment dosage forms by infrared imaging spectroscopy.
Summary of "Homogeneity study of ointment dosage forms by infrared imaging spectroscopy."
Ointment dosage forms are semi-solid preparations intended for local or transdermal delivery of active substances usually for application to the skin and it is important that they present a homogeneous appearance. In this work, a study of the homogeneity of a tacrolimus ointment dosage form was performed using infrared imaging spectroscopy coupled with principal component analysis (PCA) and multivariate curve resolution with alternating least squares (MCR-ALS) to interpret the imaging data. Optical visible microscopy images indicated possible phase separation in the ointment and, based on the results presented by distribution concentration maps from infrared imaging, it was possible to conclude that, in fact, there was phase separation incorporated in the ointment. Thus, infrared imaging spectroscopy associated to PCA and MCR-ALS is demonstrated to be a powerful tool for the development process of ointment dosage forms.
Affiliation
Institute of Chemistry, University of Campinas-UNICAMP, PO Box 6154, Campinas, SP 13083-970, Brazil.
Journal Details
This article was published in the following journal.
Name: Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Pages: 42-8
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22018891
- DOI: http://dx.doi.org/10.1016/j.jpba.2011.09.031
Medical and Biotech [MESH] Definitions
Spectroscopy, Near-infrared
A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.
Electron Spin Resonance Spectroscopy
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
Pharmaceutic Aids
Substances which are of little or no therapeutic value, but are necessary in the manufacture, compounding, storage, etc., of pharmaceutical preparations or drug dosage forms. They include SOLVENTS, diluting agents, and suspending agents, and emulsifying agents. Also, ANTIOXIDANTS; PRESERVATIVES, PHARMACEUTICAL; COLORING AGENTS; FLAVORING AGENTS; VEHICLES; EXCIPIENTS; OINTMENT BASES.
Spectroscopy, Fourier Transform Infrared
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
Suppositories
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
PubMed Articles
The two-compound ointment (Taclonex/Daivobet/Dovobet ointment) combining calcipotriene 50 microg/g and betamethasone 0.5 mg/g (as dipropionate) is very effective in the treatment of psoriasis vulgaris...
Patented Herbal Formulations and their Therapeutic Applications.
Recently, there is a greater global interest in non synthetic, natural medicines derived from plant sources due to better tolerance and minimum adverse drug reactions as compared to synthetic medicine...
Within the Process Analytical Technology (PAT) framework, it is of utmost importance to obtain critical process and formulation information during pharmaceutical processing. Process analyzers are the...
In situ analysis: Near infrared imaging spectroscopy (1000-2500 nm) is used to map the use of a fat-containing paint binder, likely egg yolk, in situ on a work of art for the first time. The ident...
Oral drug delivery in personalized medicine: unmet needs and novel approaches.
Increasing knowledge into personalized medicine has demonstrated the need for individual dosing. Drug dosage forms are urgently needed enabling an individual therapy, especially for oral drug delivery...
Clinical Trials
This study is designed to evaluate the technical performance and clinical handling of a coronary catheter that includes two imaging techniques. The catheter being evaluated performs near...
SPECTACL: SPECTroscopic Assessment of Coronary Lipid
The purpose of this study is to evaluate a near-infrared (NIR) spectroscopy system that has been designed to identify the chemical composition of coronary artery plaques in patients underg...
Assessment of Near Infrared Spectroscopy as a Diagnostic Tool in Acute Compartment Syndrome
The purpose of this study is to define the reliability and accuracy of Near Infrared Spectroscopy (NIRS) in the detection of intra-compartmental tissue perfusion in injured and noninjured...
NIRS and Doppler to Predict NEC in Risk Neonates
The main objective is to evaluate the interest of cerebro-splanchnic oxygenation ratio (CSOR) for early diagnosis of necrotizing enterocolitis (NEC) in neonates with rectal bleeding and/or...
MRI (Including Spectroscopy and Fat-Saturations and Diffusion-Weighted Imaging) in Cervical Cancer
To detect differences in MR spectroscopy, diffusion weighted MR, or dynamic contrast enhancement (DCE) MR imaging between primary cervical tumors and normal cervical tissue.
