Isolated endogenous Nocardia endophthalmitis after immunosuppression.
Summary of "Isolated endogenous Nocardia endophthalmitis after immunosuppression."
PURPOSE:
This study is aimed to report a case of endogenous Nocardia endophthalmitis in the setting of immunosuppression from chronic steroid use.
METHODS:
A case report was conducted.
RESULTS:
A 79-year-old woman presented with decreased vision with floaters in the left eye. Ophthalmic examination revealed severe inflammation in the anterior chamber, vitreous opacities, and retinal detachment. Vitreous cultures grew Nocardia farcinica without any systemic foci of infection found during further workup. The patient was treated with intravitreal amikacin and oral trimethoprim-sulfamethoxazole, and her retinal detachment was later repaired in the operating room. The patient has since remained stable with no signs of retinal detachment or active infection.
CONCLUSIONS:
Nocardia endophthalmitis is a rare, but serious intraocular infection that should be considered in the differential diagnosis in any immunosuppressed patient, including those receiving steroids, who presents with signs of intraocular infection.
Affiliation
The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Maumenee 745, Baltimore, MD, 21287, USA.
Journal Details
This article was published in the following journal.
Name: Journal of ophthalmic inflammation and infection
ISSN: 1869-5760
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22278699
- DOI: http://dx.doi.org/10.1007/s12348-011-0057-3
Medical and Biotech [MESH] Definitions
Endophthalmitis
Suppurative inflammation of the tissues of the internal structures of the eye; not all layers of the uvea are affected. Fungi, necrosis of intraocular tumors, and retained intraocular foreign bodies often cause a purulent endophthalmitis.
Formycins
Pyrazolopyrimidine ribonucleosides isolated from Nocardia interforma. They are antineoplastic antibiotics with cytostatic properties.
Pravastatin
An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).
Nocardia Infections
Infections with bacteria of the genus NOCARDIA.
Coformycin
A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.
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