Positive impact of levetiracetam on emotional learning and memory in naive mice.
Summary of "Positive impact of levetiracetam on emotional learning and memory in naive mice."
The effect of an antiepileptic drug on cognitive function is of primary importance with respect to the patient's quality of life. Levetiracetam (LEV) is a novel antiepileptic drug used to treat epilepsy, but its effects on spatial and emotional learning and memory are not yet well understood. The goal of our study was to establish the effects of LEV (17 and 54mg/kg, intraperitoneally (IP)) on spatial memory retrieval in the Morris water maze test and on acquisition and memory formation in the passive avoidance (PA) test in naive mice.
Affiliation
Kocaeli University, Department of Pharmacology, Faculty of Medicine, Psychopharmacology Laboratory, 41380, Kocaeli, Umuttepe, Turkey.
Journal Details
This article was published in the following journal.
Name: Life sciences
ISSN: 1879-0631
Pages: 185-9
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22119754
- DOI: http://dx.doi.org/10.1016/j.lfs.2011.11.003
Medical and Biotech [MESH] Definitions
Memory
Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
Transfer (psychology)
Change in learning in one situation due to prior learning in another situation. The transfer can be positive (with second learning improved by first) or negative (where the reverse holds).
Mushroom Bodies
Prominent lobed neuropils found in ANNELIDA and all ARTHROPODS except crustaceans. They are thought to be involved in olfactory learning and memory.
Emotional Intelligence
The ability to understand and manage emotions and to use emotional knowledge to enhance thought and deal effectively with tasks. Components of emotional intelligence include empathy, self-motivation, self-awareness, self-regulation, and social skill. Emotional intelligence is a measurement of one's ability to socialize or relate to others.
Nootropic Agents
Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.
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