Valvular disease in patients requiring long-term left ventricular assist devices: pathophysiology and therapeutic options.
Summary of "Valvular disease in patients requiring long-term left ventricular assist devices: pathophysiology and therapeutic options."
It is becoming clear that valvular pathology in patients requiring long-term mechanical ventricular support is an evolving, poorly understood and potentially dynamic problem. While strict guidelines are lacking, there is a growing experience in the understanding and management of the growing spectrum of valvular problems in this complex patient population. While the management of tricuspid and aortic regurgitation is of significant concern and may potentially have significant adverse impact on outcomes, other valvular pathologies can be problematic and require management in a manner unique to each patient.
Affiliation
Division of Cardiac Surgery, The Ohio State University Medical Center. Columbus, OH 43210, USA. michael.firstenberg@osumc.edu.
Journal Details
This article was published in the following journal.
Name: Expert review of cardiovascular therapy
ISSN: 1744-8344
Pages: 205-13
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22292876
- DOI: http://dx.doi.org/10.1586/erc.11.189
Medical and Biotech [MESH] Definitions
Cardiomyopathy, Hypertrophic
A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
Ventricular Function, Left
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Isolated Noncompaction Of The Ventricular Myocardium
Rare congenital cardiomyopathies characterized by the lack of left ventricular myocardium compaction. The noncompaction results in numerous prominent trabeculations and a loose myocardial meshwork (spongy myocardium) in the LEFT VENTRICLE. Heterogeneous clinical features include diminished systolic function sometimes associated with left ventricular dilation, that presents either neonatally or progressively. Often, the RIGHT VENTRICLE is also affected. CONGESTIVE HEART FAILURE; PULMONARY EMBOLISM; and ventricular ARRHYTHMIA are commonly seen.
Tricuspid Atresia
Absence of the orifice between the RIGHT ATRIUM and RIGHT VENTRICLE, with the presence of an atrial defect through which all the systemic venous return reaches the left heart. As a result, there is left ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR) because the right ventricle is absent or not functional.
Ventricular Dysfunction, Left
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
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