Abnormal brain structure implicated in stimulant drug addiction.

16:39 EST 21st December 2014 | BioPortfolio

Summary of "Abnormal brain structure implicated in stimulant drug addiction."

Addiction to drugs is a major contemporary public health issue, characterized by maladaptive behavior to obtain and consume an increasing amount of drugs at the expense of the individual's health and social and personal life. We discovered abnormalities in fronto-striatal brain systems implicated in self-control in both stimulant-dependent individuals and their biological siblings who have no history of chronic drug abuse; these findings support the idea of an underlying neurocognitive endophenotype for stimulant drug addiction.

Affiliation

Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK. ke220@cam.ac.uk

Journal Details

This article was published in the following journal.

Name: Science (New York, N.Y.)
ISSN: 1095-9203
Pages: 601-4

Links

PubMed Articles [23095 Associated PubMed Articles listed on BioPortfolio]

Cellular basis of memory for addiction.

DESPITE THE IMPORTANCE OF NUMEROUS PSYCHOSOCIAL FACTORS, AT ITS CORE, DRUG ADDICTION INVOLVES A BIOLOGICAL PROCESS: the ability of repeated exposure to a drug of abuse to induce changes in a vulnerabl...

EXAMINATION OF NEURAL SYSTEMS SUB-SERVING FACEBOOK "ADDICTION" (.)

Summary.-Because addictive behaviors typically result from violated homeostasis of the impulsive (amygdala-striatal) and inhibitory (prefrontal cortex) brain systems, this study examined whether these...

An increase in tobacco craving is associated with enhanced medial prefrontal cortex network coupling.

Craving is a key aspect of drug dependence that is thought to motivate continued drug use. Numerous brain regions have been associated with craving, suggesting that craving is mediated by a distribute...

A new proposal for drug conditioning with implications for drug addiction: The Pavlovian two-step from delay to trace conditioning.

Pavlovian conditioning of drug effects is generally acknowledged to be a critical factor in the development and persistence of drug addiction. In drug conditioning the focus has essentially been on on...

Zebrafish and conditioned place preference: A translational model of drug addiction.

Addiction and substance abuse are found ubiquitously throughout human society. In the United States, these disorders are responsible for amassing hundreds of billions of dollars in annual costs associ...

Clinical Trials [3857 Associated Clinical Trials listed on BioPortfolio]

Four Models of Telephone Support for Stimulant Recovery

The overall objective of this research is to develop and refine empirically supported continuing care interventions that promote healthy behavior and sustained abstinence from illicit drug...

Brain Changes in Stimulant Dependent Subjects - 8

The purpose of this study is to identify the neurophysiologic indicators of cocaine or methamphetamine use and withdrawal, to examine the relationship between subjects' reports of depressi...

Evaluation of Functional MRI and DTI (Imaging Techniques) in Children With Epilepsy and Focal Brain Lesions

This study is being done to look at the relationship between brain structure and brain function in patients with epilepsy or focal brain lesions (abnormal areas) that require surgery. Thi...

Effects of Maternal Body Composition on Offspring Brain Structure and Function

The specific aim of this study is to use MRI methods to evaluate and compare brain structure and function in two groups of full-term neonates at two-weeks of age: those born of obese mothe...

Neuroimaging of the Effects of Concerta in the Treatment of ADHD

A number of brain regions have been down to be altered in both structure and function in patients with ADHD, including prefrontal cortex, anterior cingulate, caudate and cerebellum. Patie...

Medical and Biotech [MESH] Definitions

A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simple tasks. It may be related to DEPRESSION or DRUG ADDICTION.

Adjustment of BRAIN WAVES from two or more neuronal groups within or across a brain structure (e.g., cortical and limbic brain structures) to become uniform in EEG oscillation patterns in response to a stimulus. It is interpreted as a brain integration sign during many processes such as learning, memory, and perception and involves reciprocal neural connections.

A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)

A CNS stimulant that is used to induce convulsions in experimental animals. It has also been used as a respiratory stimulant and in the treatment of barbiturate overdose.

Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.

Search BioPortfolio:
Loading
Advertisement

Relevant Topics

Alzheimer's Disease
Latest News Clinical Trials Research Drugs Reports Corporate
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase  'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...

Public Health
Latest News Clinical Trials Research Drugs Reports Corporate
Public health is the scientific, political and sociological approach by a society to maximise the health of the population through disease preventaion and mainenance of healthy life-styles. The mains areas of public health are epidemiology, biostatistics...

Advertisement