Iranian Breast Cancer Bio-Bank: the activity and challenging issues.
Summary of "Iranian Breast Cancer Bio-Bank: the activity and challenging issues."
The information gained from the Human Genome Project has facilitated molecular as well as cellular studies not only to find the origins of Breast Cancer (BC), but also to create novel, and effective treatments. In order to provide an infrastructure for local and international research in this area, Iranian Center for Breast Cancer (ICBC) has established a Bio-Bank (BB) for BC. This article describes the aim, structure, and activities in general, and the challenging issues confronting the bank as a model for the establishment of Bio-Banks in developing countries in particular. The methods employed by the Bank could be explained in the following categories: Blood and Tissue sampling, Preparation and Banking of collected Samples, Clinical and Histopathology data collection, Collaboration Protocol, Challenging issues, and the programs to confront the problems. During the five-year activity of the bank, 110 families were enrolled for genetic counseling, from whom 600 biologic samples were obtained, including 387 blood samples and 213 tissue samples. Of 387 blood samples, 317 (82%) were found to belong to the BC patients and the remaining 70 (18%) belonged to their available relatives. The number of samples increased over the study period partly as a result of the programs designed to confront the problems. During the study period, there were some finished research studies using the samples of BB, and many other studies which are still ongoing. ICBC-BB is a model of biologic sample banking which provides a significant number of biological samples for local and international collaborative research projects regarding molecular and cellular aspects of BC. In establishing the ICBC-BB we have experienced problems and challenges, some general and some local. Some were expected and others not, but we have identified solutions.
Affiliation
Iranian Center for Breast Cancer (ICBC); Academic Center for Education, Culture and Research (ACECR), No 45, Nazari St, Abureihan St, Enghelab Ave, PO Box: 14155-6615, Tehran, Iran, kmajidzadeh@razi.tums.ac.ir.
Journal Details
This article was published in the following journal.
Name: Cell and tissue banking
ISSN: 1573-6814
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22318652
- DOI: http://dx.doi.org/10.1007/s10561-012-9293-5
Medical and Biotech [MESH] Definitions
Inflammatory Breast Neoplasms
Metastatic breast cancer characterized by EDEMA and ERYTHEMA of the affected breast due to LYMPHATIC METASTASIS and eventual obstruction of LYMPHATIC VESSELS by the cancer cells.
Carcinoma, Lobular
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
Mucin-1
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
Breast Neoplasms
Tumors or cancer of the human BREAST.
Idarubicin
An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
PubMed Articles
To evaluate the association between breast cancer and cytosine-adenine (CA) dinucleotide repeat length polymorphisms in the promoter region of the Insulin-like Growth Factor 1 (IGF-1) gene, a case-con...
Lymphedema and breast cancer: a review of the literature.
Breast cancer continues to be the most common malignancy among women in the United States. Despite its high incidence, early detection and modern treatment have made long-term survival more common. On...
Knowledge of Breast Cancer and Screening Practices Among Iranian Immigrant Women in Toronto.
Breast cancer is a leading cause of mortality and morbidity in Canada. Secondary prevention through screening may enable early identification and treatment, but this is suboptimal among all Canadian w...
We aimed to investigate the association of insertion/deletion (I/D) and A1166C polymorphisms of angiotensin I converting enzyme 1 and angiotensin II type 1 receptor genes, respectively and their combi...
Both obesity and breast cancer incidence increased dramatically during two recent decades in a rapidly changing society in northern Iran. In this study, we examined the ability of body mass index (BMI...
Clinical Trials
Extended Follow-up of Columbia, MO Serum Bank Participants
The purpose of this investigation is to extend follow-up to ascertain cancer diagnoses and deaths through the present time among women who donated serum to the Columbia, MO serum bank. Al...
RATIONALE: Physical activity may be effective in preventing the development or recurrence of breast cancer. PURPOSE: This randomized clinical trial is studying physical activity to see ho...
Primary Progesterone Therapy for Operable Breast Cancer
The purpose of this study is to test the effect of primary progesterone on overall and disease free survival in women with operable breast cancer. The study addresses two issues related to...
Community Volunteers Promoting Physical Activity Among Cancer Survivors
Physical activity programs, when offered in research settings, have been shown to improve quality of life and reduce fatigue among breast cancer survivors. The investigators are training...
Deep Sequencing of the Breast Cancer Transcriptome
This project is a pilot study designed to investigate transcriptional regulation in breast cancer. Although the main focus of the present study will be triple negative breast cancer where...
