Hippocampal long term potentiation in rats under different regimens of vitamin D: An in vivo study.
Summary of "Hippocampal long term potentiation in rats under different regimens of vitamin D: An in vivo study."
Evidence indicates that vitamin D involves in development of brain as well as its function. This study assesses occurrence of long term potentiation (LTP), as an experimental form of synaptic plasticity, in adult rats under the normal regimen (CON), and the regimens without vitamin D (CON-D) or with a supplement of 1,25(OH)2D3 (CON+D). Stimulating the Schaffer collaterals pre- and post-tetanus excitatory postsynaptic potentials (EPSPs) were recorded in the CA1 area of hippocampus in anesthetized animals. Amplitude change of the EPSPs was considered for comparisons. Our results indicated that the basic EPSPs were similar in the three groups. Tetanization elicited a considerable LTP in both the CON and CON+D rats but a moderate potentiation in the CON-D group. We concluded that optimal level of vitamin D is required for induction of LTP.
Physiology Research Center, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.
This article was published in the following journal.
Name: Neuroscience letters
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22227619
- DOI: http://dx.doi.org/10.1016/j.neulet.2011.12.050
Medical and Biotech [MESH] Definitions
A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.
An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.
A nervous tissue specific protein which is highly expressed in NEURONS during development and NERVE REGENERATION. It has been implicated in neurite outgrowth, long-term potentiation, SIGNAL TRANSDUCTION, and NEUROTRANSMITTER release. (From Neurotoxicology 1994;15(1):41-7) It is also a substrate of PROTEIN KINASE C.
Rats, Inbred Oletf
An inbred strain of Long-Evans rats that develops hyperglycemia, hyperinsulinemia, and mild obesity, mostly in males, that resembles non-insulin-dependent diabetes mellitus in humans. It was developed from outbred Long-Evans stock in 1983.
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