Does the endogenous neurogenic response alter behavioral recovery following stroke?
Summary of "Does the endogenous neurogenic response alter behavioral recovery following stroke?"
In response to stroke, the adult brain has the remarkable ability to enhance the proliferation of new cells, which form new neurons in restricted regions. This review focuses on studies that have directly tested the hypothesis that neurogenesis contributes to post-stroke behavioral recovery. The translational potential of this area of research is critically assessed with respect to the selection of appropriate stroke models, subjects, neurogenic regions examined, behavioral tests used, and experimental timecourse. Building upon those studies that suggest an association between endogeneous neurogenesis and improved stroke recovery, we are nonetheless left with the challenge to demonstrate a causal link between neurogenesis and behavioral recovery using new technology.
Department of Cellular and Molecular Medicine, University of Ottawa, Ontario, Canada.
This article was published in the following journal.
Name: Behavioural brain research
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/21907736
- DOI: http://dx.doi.org/10.1016/j.bbr.2011.08.045
Medical and Biotech [MESH] Definitions
Behavioral response associated with the achieving of gratification.
Research that involves the application of the behavioral and social sciences to the study of the actions or reactions of persons or animals in response to external or internal stimuli. (from American Heritage Dictionary, 4th ed)
The interference with or prevention of a behavioral or verbal response even though the stimulus for that response is present; in psychoanalysis the unconscious restraining of an instinctual process.
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The process by which an emotional or behavioral response that is appropriate for one situation appears in another situation for which it is inappropriate.
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