The Glutamatergic Neurotransmission in the Central Nervous System.
Summary of "The Glutamatergic Neurotransmission in the Central Nervous System."
Glutamate is one of the major neurotrasmitters in mammalian brain and changes in its concentration have been associated with a number of neurological disorders, including neurodegenerative, cerebrovascular diseases and epilepsy. Moreover, recently a possible role for glutamatergic system dysfunction has been suggested also in the peripheral nervous system. This chapter will revise the current knowledge in the distribution of glutamate and of its receptors and transporters in the central nervous system.
Affiliation
Department of Neuroscience and Biomedical Technologies, University of Milano-Bicocca, Via Cadore 48, 20900 Monza (MB), Italy. paola.marmiroli@unimib.it.
Journal Details
This article was published in the following journal.
Name: Current medicinal chemistry
ISSN: 1875-533X
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22338563
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Glutamate Plasma Membrane Transport Proteins
A family of plasma membrane neurotransmitter transporter proteins that couple the uptake of GLUTAMATE with the import of SODIUM ions and PROTONS and the export of POTASSIUM ions. In the CENTRAL NERVOUS SYSTEM they regulate neurotransmission through synaptic reuptake of the excitatory neurotransmitter glutamate. Outside the central nervous system they function as signal mediators and regulators of glutamate metabolism.
Autonomic Nervous System
The enteric, parasympathetic, and sympathetic nervous systems taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the central nervous system, especially the hypothalamus and the solitary nucleus, which receive information relayed from VISCERAL AFFERENTS; these and related central and sensory structures are sometimes (but not here) considered to be part of the autonomic nervous system itself.
Lithium Carbonate
A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.
Hereditary Central Nervous System Demyelinating Diseases
Inherited conditions characterized by a loss of myelin in the central nervous system.
Nervous System Physiological Phenomena
Characteristic properties and processes of the NERVOUS SYSTEM as a whole or with reference to the peripheral or the CENTRAL NERVOUS SYSTEM.
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