Comparative Evaluation of Autologous Platelet-Rich Fibrin and Platelet-Rich Plasma in the Treatment of Three-Wall Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial.

03:48 EDT 1st August 2015 | BioPortfolio

Summary of "Comparative Evaluation of Autologous Platelet-Rich Fibrin and Platelet-Rich Plasma in the Treatment of Three-Wall Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial."

Background: The topical use of platelet concentrates is recent and its efficiency remains controversial. The present study aimed to explore the clinical and radiographical effectiveness of autologous platelet rich fibrin (PRF) and platelet rich plasma (PRP) in treatment of intrabony defects in chronic periodontitis subjects. Material and Methods: 90 intrabony defects were treated either with autologous PRF with open flap debridement or autologous PRP with open flap debridement or open flap debridement alone. Clinical and radiological parameters such as probing depth (PD), clinical attachment level (CAL), intrabony defect depth and % defect fill were recorded at baseline and 9 months postoperatively. Results: Mean PD reduction and CAL gain was greater in PRF (3.77 + 1.19 mm, 3.17 + 1.29 mm) and PRP (3.77 + 1.07 mm, 2.93 + 1.08 mm) groups than control group (2.97 ± 0.93 mm, 2.83 ± 0.91 mm). Furthermore, significantly greater percentage of mean bone fill was found in the PRF (55.41 + 11.39 %) and PRP (56.85 + 14.01 %) compared to control (1.56 ± 15.12 %). Conclusions: Within the limit of the present study, there was similar PD reduction, CAL gain and bone fill at sites treated with PRF or PRP with conventional open flap debridement. Since PRF is less time consuming and less technique sensitive it may seem as the better among the two. However, long term, multicenter randomized, controlled clinical trials will be required to know their clinical and radiographical effects over bone regeneration.

Affiliation

Dept of Periodontics, Govt. Dental College & Research Institute, Bangalore 560002.

Journal Details

This article was published in the following journal.

Name: Journal of periodontology
ISSN: 1943-3670
Pages:

Links

PubMed Articles [10379 Associated PubMed Articles listed on BioPortfolio]

Platelet rich fibrin in maxillary sinus augmentation: A systematic review.

Abstract The aim of this study was to systemically assess the efficacy of platelet rich fibrin (PRF) on maxillary sinus augmentation using the lateral approach. A PUBMED search, hand search of relevan...

Micro-computed tomography and histomorphometric analysis of the effects of platelet-rich fibrin on bone regeneration in the rabbit calvarium.

The present study aimed to investigate the effectiveness of platelet-rich fibrin (PRF) on bone regeneration when used alone or in combination with hydroxyapatite (HA)/beta-tricalcium phosphate (βTCP)...

Evaluation of the anti-inflammatory effects of two platelet-rich gel supernatants in an in vitro system of cartilage inflammation.

To study, in normal cartilage explants (CEs) challenged with lipopolysaccharide (LPS), the temporal effects (at 48 and 96h) of leukocyte- and platelet-rich gel (L-PRG) and pure platelet-rich gel (P-PR...

Effects of platelet-rich fibrin and piezosurgery on impacted mandibular third molar surgery outcomes.

The aim of this study was the comparision of postoperative outcomes in impacted mandibular third molars that were treated using either platelet-rich fibrin (PRF), a combination of PRF and piezosurgery...

Use of an autologous leucocyte and platelet-rich fibrin patch on hard-to-heal DFUs: a pilot study.

Leucopatch is a leukocyte and platelet-rich fibrin patch that provides concentrated blood cells and signal substances to the surface of an ulcer. It is produced by centrifugation of the patient's own ...

Clinical Trials [2589 Associated Clinical Trials listed on BioPortfolio]

Evaluation of the Mechanism of Action of Platelet Rich Fibrin Matrix (PRFM) in Producing Skin Volume Augmentation

Autologous platelet rich fibrin matrix will release growth factors which could increase the production of dermal proteins or affect the vascularity and status of neighboring tissues. This ...

Treatment of Periodontal Intrabony Defects Using Autologous Platelet Rich Fibrin vs Titanium Platelet Rich Fibrin

Background: To compare the effectiveness of open flap debridement (OFD) alone and OFD along with either Autologous Platelet Rich Fibrin (PRF) or Titanium Platelet Rich Fibrin (TPRF) in the...

Clinical, Histological and Micro-computed Tomographic Evaluation of Neoformed Tissue in Post-extraction Sockets Covered With Platelet-rich Fibrin (PRF) Membrane: a Randomized Controlled Trial

The platelet-rich fibrin (PRF), belongs to a new generation of plasma concentrate with biomechanical processing simplified and without the need for handling blood biochemistry. Some studie...

Applying Platelet Rich Plasma (PRP) Gel to Acute Deep Partial Thickness Thermal Injuries

The study will examine the safety of using a concentration of proteins from a patient's own blood, referred to as platelet rich plasma or (PRP) and applying it to a second degree burn woun...

Impact of Autologous Platelet Rich Plasma on Healing of Rotator Cuff Repairs

Partial-thickness and full-thickness rotator cuff tears are common soft-tissue conditions that often require surgical treatment. Initial efforts to improve tendon healing centered on impro...

Medical and Biotech [MESH] Definitions

Retraction of a clot resulting from contraction of PLATELET pseudopods attached to FIBRIN strands. The retraction is dependent on the contractile protein thrombosthenin. Clot retraction is used as a measure of platelet function.

A rare, inherited platelet disorder characterized by a selective deficiency in the number and contents of platelet alpha-granules. It is associated with THROMBOCYTOPENIA, enlarged platelets, and prolonged bleeding time.

Human alloantigens expressed only on platelets, specifically on platelet membrane glycoproteins. These platelet-specific antigens are immunogenic and can result in pathological reactions to transfusion therapy.

A preparation consisting of PLATELETS concentrated in a limited volume of PLASMA. This is used in various surgical tissue regeneration procedures where the GROWTH FACTORS in the platelets enhance wound healing and regeneration.

Platelet membrane glycoprotein IIb is an integrin alpha subunit that heterodimerizes with INTEGRIN BETA3 to form PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX. It is synthesized as a single polypeptide chain which is then postranslationally cleaved and processed into two disulfide-linked subunits of approximately 18 and 110 kDa in size.


Advertisement
 

Relevant Topics

Blood
Latest News Clinical Trials Research Drugs Reports Corporate
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Clincial Trials
Latest News Clinical Trials Research Drugs Reports Corporate
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...

Osteoporosis
Latest News Clinical Trials Research Drugs Reports Corporate
Osteoporosis is a disease in which the bones become extremely porous, are subject to fracture, and heal slowly, occurring especially in women following menopause and often leading to curvature of the spine from vertebral collapse. Follow and track&n...

Advertisement
 

Searches Linking to this Article