Comparative Evaluation of Autologous Platelet-Rich Fibrin and Platelet-Rich Plasma in the Treatment of Three-Wall Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial.

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Summary of "Comparative Evaluation of Autologous Platelet-Rich Fibrin and Platelet-Rich Plasma in the Treatment of Three-Wall Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial."

Background: The topical use of platelet concentrates is recent and its efficiency remains controversial. The present study aimed to explore the clinical and radiographical effectiveness of autologous platelet rich fibrin (PRF) and platelet rich plasma (PRP) in treatment of intrabony defects in chronic periodontitis subjects. Material and Methods: 90 intrabony defects were treated either with autologous PRF with open flap debridement or autologous PRP with open flap debridement or open flap debridement alone. Clinical and radiological parameters such as probing depth (PD), clinical attachment level (CAL), intrabony defect depth and % defect fill were recorded at baseline and 9 months postoperatively. Results: Mean PD reduction and CAL gain was greater in PRF (3.77 + 1.19 mm, 3.17 + 1.29 mm) and PRP (3.77 + 1.07 mm, 2.93 + 1.08 mm) groups than control group (2.97 ± 0.93 mm, 2.83 ± 0.91 mm). Furthermore, significantly greater percentage of mean bone fill was found in the PRF (55.41 + 11.39 %) and PRP (56.85 + 14.01 %) compared to control (1.56 ± 15.12 %). Conclusions: Within the limit of the present study, there was similar PD reduction, CAL gain and bone fill at sites treated with PRF or PRP with conventional open flap debridement. Since PRF is less time consuming and less technique sensitive it may seem as the better among the two. However, long term, multicenter randomized, controlled clinical trials will be required to know their clinical and radiographical effects over bone regeneration.


Dept of Periodontics, Govt. Dental College & Research Institute, Bangalore 560002.

Journal Details

This article was published in the following journal.

Name: Journal of periodontology
ISSN: 1943-3670


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