Protein-protein interaction inhibitors get into the groove.
Summary of "Protein-protein interaction inhibitors get into the groove."
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Journal Details
This article was published in the following journal.
Name: Nature reviews. Drug discovery
ISSN: 1474-1784
Pages: 173-5
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22378255
- DOI: http://dx.doi.org/10.1038/nrd3680
Medical and Biotech [MESH] Definitions
Pdz Domains
Protein interaction domains of about 70-90 amino acid residues, named after a common structure found in PSD-95, Discs Large, and Zona Occludens 1 proteins. PDZ domains are involved in the recruitment and interaction of proteins, and aid the formation of protein scaffolds and signaling networks. This is achieved by sequence-specific binding between a PDZ domain in one protein and a PDZ motif in another protein.
Protein Interaction Domains And Motifs
Protein modules with conserved ligand-binding surfaces which mediate specific interaction functions in SIGNAL TRANSDUCTION PATHWAYS and the specific BINDING SITES of their cognate protein LIGANDS.
Protein Array Analysis
Ligand-binding assays that measure protein-protein, protein-small molecule, or protein-nucleic acid interactions using a very large set of capturing molecules, i.e., those attached separately on a solid support, to measure the presence or interaction of target molecules in the sample.
Protein Interaction Mapping
Methods for determining interaction between proteins.
Protein Kinase Inhibitors
Agents that inhibit PROTEIN KINASES.
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