Cell biology. Reconfiguring regulation.
Summary of "Cell biology. Reconfiguring regulation."
No Summary Available
Affiliation
MRC Laboratory of Molecular Biology, Cambridge, UK.
Journal Details
This article was published in the following journal.
Name: Science (New York, N.Y.)
ISSN: 1095-9203
Pages: 1050-1
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22383834
- DOI: http://dx.doi.org/10.1126/science.1219303
Medical and Biotech [MESH] Definitions
Cell-free System
A fractionated cell extract that maintains a biological function. A subcellular fraction isolated by ultracentrifugation or other separation techniques must first be isolated so that a process can be studied free from all of the complex side reactions that occur in a cell. The cell-free system is therefore widely used in cell biology. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p166)
Cullin Proteins
A family of structurally related proteins that were originally discovered for their role in cell-cycle regulation in CAENORHABDITIS ELEGANS. They play important roles in regulation of the CELL CYCLE and as components of UBIQUITIN-PROTEIN LIGASES.
Sodium-hydrogen Antiporter
A plasma membrane exchange glycoprotein transporter that functions in intracellular pH regulation, cell volume regulation, and cellular response to many different hormones and mitogens.
Chromosomes
In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Receptors, Cell Surface
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
PubMed Articles
An MBoC Favorite: Regulation of the vitellogenin receptor during Drosophila melanogaster oogenesis.
Cell adhesion in regulation of asymmetric stem cell division.
Adult stem cells inevitably communicate with their cellular neighbors within the tissues they sustain. Indeed, such communication, particularly with components of the stem cell niche, is essential for...
Coordination between RAB GTPase and phosphoinositide regulation and functions.
Membrane trafficking relies on dynamic changes in membrane identities that are determined by the regulation of distinct RAB GTPases and phosphoinositides. RABs and phosphoinositides both act to spatio...
Life and death in the thymus-cell death signaling during T cell development.
The thymus is an organ vital to proper T cell development, and the regulation of cell survival and death contributes significantly to its efficient function. Vital to many of the developmental process...
Clinical Trials
The Molecular Biology of Paroxysmal Nocturnal Hemoglobinuria (PNH)
This study is designed to better understand the molecular biology of paroxysmal nocturnal hemoglobinuria (PNH) and to determine if prion protein (PrP) functions in long term hematopoietic...
The purpose of this pilot study is to determine whether incorporating self-regulation training using daily weighing is efficacious within a behavioral weight loss program specifically targ...
Evaluation of Chemotherapy Influence on Clinical and Biological Markers of Ovarian Reserve
The objective is to evaluate the influence of chemotherapy, either for auto-immune disease, either for carcinologic disease, on clinical and biological markers of ovarian reserve, for youn...
The purpose of the Brain, Biology and Mood study is to examine the association between stress, depression and cell death in the hippocampus. We fully expect this study to highlight compone...
The Derivation of Human Embryonic Stem Cell Lines From PGD Embryos
Human embryonic stem cells (hESCs) are isolated from the early human embryo and have the capability to proliferate indefinitely in culture and to develop into nearly every cell of the huma...
