Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-(2-oxocyclopentyl)methylphenyl}propanoic acid: Non-steroidal Anti-inflammatory Drugs with Low Gastric Ulcerogenic Activity.
Summary of "Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-(2-oxocyclopentyl)methylphenyl}propanoic acid: Non-steroidal Anti-inflammatory Drugs with Low Gastric Ulcerogenic Activity."
We previously reported that 2-fluoroloxoprofen has lower gastric ulcerogenic activity than loxoprofen, a non-steroidal anti-inflammatory drug (NSAID) without selectivity for COX-2. We synthesized derivatives of 2-fluoroloxoprofen and studied their properties. Compared to 2-fluoroloxoprofen, one derivative, 11a, exhibited higher anti-inflammatory activity and an equivalent ulcerogenic effect. These results suggest that 11a could be therapeutically beneficial for use as an NSAID.
Affiliation
Journal Details
This article was published in the following journal.
Name: Journal of medicinal chemistry
ISSN: 1520-4804
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22404396
- DOI: http://dx.doi.org/10.1021/jm300049g
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Drug Evaluation, Preclinical
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