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The induced aggregation of achiral building blocks by a chiral species to form chiral aggregates with memorized chirality has been observed for a number of systems. However, chiral memory in isolated aggregates of achiral building blocks remains rare. One possible reason for this discrepancy could be that not much is understood in terms of designing these chiral aggregates. Herein, we report a strategy for creating such isolable chiral aggregates from achiral building blocks that retain chiral memory after the facile physical removal of the chiral templates. This strategy was used for the isolation of chiral homoaggregates of neutral achiral π-conjugated carboxylic acids in pure aqueous solution. Under what we have termed an "interaction-substitution" mechanism, we generated chiral homoaggregates of a variety of π-conjugated carboxylic acids by using carboxymethyl cellulose (CMC) as a mediator in acidic aqueous solutions. These aggregates were subsequently isolated from the CMC templates whilst retaining their memorized supramolecular chirality. Circular dichroism (CD) spectra of the aggregates formed in the acidic CMC solution exhibited bisignated exciton-coupled signals of various signs and intensities that were maintained in the isolated pure homoaggregates of the achiral π-conjugated carboxylic acids. The memory of the supramolecular chirality in the isolated aggregates was ascribed to the substitution of COOH/COOH hydrogen-bonding interaction between the carboxylic acid groups within the aggregates for the hydrogen-bonding interactions between the COOH groups of the building blocks and the chiral templates. We expect that this "interaction-substitution" procedure will open up a new route to isolable pure chiral aggregates from achiral species.
This article was published in the following journal.
Name: Chemistry (Weinheim an der Bergstrasse, Germany)
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Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.
Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and a carboxylic acid anion.
Compounds consisting of chains of AMINO ACIDS alternating with CARBOXYLIC ACIDS via ester and amide linkages. They are commonly cyclized.
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
Carboxylic acids that have open-chain molecular structures as opposed to ring-shaped structures.