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Physiologic insulin delivery with insulin feedback: A control systems perspective.

Summary of "Physiologic insulin delivery with insulin feedback: A control systems perspective."

Individuals with type 1 diabetes mellitus must effectively manage glycemia to avoid acute and chronic complications related to aberrations of glucose levels. Because optimal diabetes management can be difficult to achieve and burdensome, research into a closed-loop insulin delivery system has been of interest for several decades. This paper provides an overview, from a control systems perspective, of the research and development effort of a particular algorithm-the external physiologic insulin delivery system. In particular the introduction of insulin feedback, based on beta-cell physiology, is covered in detail. A summary of human clinical trials is provided in the context of the evolution of this algorithm, and this paper outlines some of the research avenues that show particular promise.

Affiliation

Medtronic Diabetes, Closed Loop R&D, 18000 Devonshire St., Northridge, CA 91325, USA.

Journal Details

This article was published in the following journal.

Name: Computer methods and programs in biomedicine
ISSN: 1872-7565
Pages:

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Medical and Biotech [MESH] Definitions

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A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

Insulin formulation containing substance which delays or retards time period of the absorption of insulin.

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