Functional Heartburn: Definition and Management Strategies.

11:12 EDT 21st October 2014 | BioPortfolio

Summary of "Functional Heartburn: Definition and Management Strategies."

Functional heartburn (FH) is a functional gastro-intestinal disorder characterized by symptoms of heartburn not related to gastro-esophageal reflux. The absence of evidence of reflux-related symptoms relies on absence of esophagitis at endoscopy (including biopsies to exclude eosinophilic esophagitis), a normal esophageal acid exposure during esophageal pH-monitoring together with a negative symptom-reflux association analysis and an unsatisfactory response to proton pump inhibitor therapy. Addition of impedance measurement to pH-monitoring is likely to increase the number of patients with recognized reflux-related symptoms. The pathophysiology of functional heartburn remains largely unknown but involves disturbed esophageal perception and psychological factors such as depression, anxiety and somatization. The treatment of FH remains largely empirical and an individual approach is therefore recommended. The clinician should provide reassurance and refrain from performing too many invasive tests or therapeutic procedures. The use of pain modulators is recommended by most experts despite the lack of appropriate clinical trials to support it.

Affiliation

Gastroenterology and Hepatology Department, Saint André Hospital, Centre Hospitalier Universitaire de Bordeaux; Université Bordeaux Segalen, Bordeaux, France, frank.zerbib@chu-bordeaux.fr.

Journal Details

This article was published in the following journal.

Name: Current gastroenterology reports
ISSN: 1534-312X
Pages:

Links

PubMed Articles [18374 Associated PubMed Articles listed on BioPortfolio]

Esophageal baseline impedance levels in patients with pathophysiological characteristics of functional heartburn.

Recently, it has been suggested that low esophageal basal impedance may reflect impaired mucosal integrity and increased acid sensitivity. We aimed to compare baseline impedance levels in patients wit...

Histamine2-receptor antagonists: Rapid development of tachyphylaxis with repeat dosing.

Histamine2-receptor antagonists (H2RAs) are available over-the-counter (OTC) for the treatment and prevention of heartburn, but more than occasional, single-dose use can lead to rapid development of t...

Evolving treatment strategies for colorectal cancer: A critical review of current therapeutic options.

Management of rectal cancer has markedly evolved over the last two decades. New technologies of staging have allowed a more precise definition of tumor extension. Refinements in surgical concepts and ...

Planning strategies in disability management.

Successful disability management practice is a systemic approach to vocational rehabilitation that begins with planning at the organizational level. A strategic planning format is used to outline the ...

Treatment Strategies for Missing Maxillary Central Incisor-An Orthodontist's Perspective.

The loss of maxillary central incisors at an early age has psychological, esthetic, and functional implications. Multiple treatment options are available for replacing missing central incisors. The ma...

Clinical Trials [2916 Associated Clinical Trials listed on BioPortfolio]

Efficacy/Safety of Lansoprazole in Patients With Frequent Heartburn

Heartburn, a burning sensation in the chest or throat, occurs in many patients when acidic stomach contents move into the esophagus from the stomach. This study will investigate the safet...

Efficacy/Safety of Lansoprazole in Patients With Frequent Nighttime Heartburn

Heartburn, a burning sensation in the chest or throat, occurs in many individuals when acidic stomach contents move upward into the esophagus from the stomach. This study will investigate...

The Safety and Efficacy of Dexloxiglumide for the Relief of Symptoms of Functional Dyspepsia.

"Functional dyspepsia" has been defined loosely as "pain or discomfort centered in the upper abdomen." The symptoms can also include fullness, early satiety, bloating, belching, nausea, r...

The Role of Tegaserod Therapy in the Management of Dyspeptic Symptoms in Female Patients on Proton Pump Inhibitors for the Treatment of Heartburn.

Study to provide initial data to assess the safety and efficacy of tegaserod use in patients with dyspepsia that are being treated with proton pump inhibitors (PPI's) for heartburn.

Proof of Concept Study Efficacy of an Antacid/Lansoprazole Combination for Relief of Heartburn

This study will investigate the safety and efficacy of an antacid/Lansoprazole combination product for the relief of heartburn after consuming a heartburn-inducing meal.

Medical and Biotech [MESH] Definitions

Management control systems for structuring health care delivery strategies around case types, as in DRGs, or specific clinical services.

The management of all procurement, distribution, and storage of equipment and supplies, as well as logistics management including laundry, processing of reusables, etc.

Participation of employees with management as a labor-management team, in decisions pertaining to the operational activities of the organization or industry.

Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.

Business management of medical and dental practices that may include capital financing, utilization management, and arrangement of capitation agreements with other parties.

Search BioPortfolio:
Loading
Advertisement

Relevant Topic

Psychiatry
Latest News Clinical Trials Research Drugs Reports Corporate
Psychiatry is the study of mental disorders and their diagnosis, management and prevention.  Conditions include schizophrenia, severe depression and panic disorders among others. There are pharmaceutical treatments as well as other therapies to help...

Advertisement