Chiral acid selectivity displayed by PEDOT electropolymerised in the presence of chiral molecules.
Summary of "Chiral acid selectivity displayed by PEDOT electropolymerised in the presence of chiral molecules."
Chiral conducting polymers prepared by electropolymerising PEDOT in the presence of chiral anions such as hyaluronic acid and anionic collagen or in a chiral nematic phase (hydroxypropyl cellulose, HPC) show excellent chiral acid recognition. This paper demonstrates the enantioselective recognition and transfer of protonated mandelic acid and protons using chiral PEDOTs. Discrimination between (R)-(-)- and (S)-(+)-mandelic acid was observed using cyclic voltammetry and square-wave voltammetry.
Affiliation
Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK. ritu.kataky@durham.ac.uk.
Journal Details
This article was published in the following journal.
Name: The Analyst
ISSN: 1364-5528
Pages: 2386-93
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22457873
- DOI: http://dx.doi.org/10.1039/c2an15854j
Medical and Biotech [MESH] Definitions
Peptoids
Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.
Amino Acid Isomerases
Enzymes that catalyze either the racemization or epimerization of chiral centers within amino acids or derivatives. EC 5.1.1.
Carbohydrate Epimerases
Enzymes that catalyze the epimerization of chiral centers within carbohydrates or their derivatives. EC 5.1.3.
Transient Receptor Potential Channels
A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
Esterification
The process of converting an acid into an alkyl or aryl derivative. Most frequently the process consists of the reaction of an acid with an alcohol in the presence of a trace of mineral acid as catalyst or the reaction of an acyl chloride with an alcohol. Esterification can also be accomplished by enzymatic processes.
PubMed Articles
We prepared the diastereoisomers of BINOL based bisboronic acid chiral probes (the probes are with dual chirogenic centers) for enantioselective recognition of chiral analytes, such as tartaric acids,...
The chiral Brønsted acid (1b or 1c) has been shown to initiate the Hosomi-Sakurai reaction of imines with excellent enantioselectivities. The combined Brønsted acid system has been developed to offe...
Developing of alternative chiral thiol stabilizers from the assembly of achiral thiol (e.g. thioglycolic acid) and chiral ligand (e.g. arginine) via both hydrogen bonding and electrostatic interaction...
Chiral crown ethers have been widely used in the resolution of various chiral compounds containing a primary amino group. Covalently bonded chiral stationary phases derived from (18-crown-6)-2,3,11,12...
Described herein is the enantioselective synthesis of multisubstituted biaryl derivatives by chiral phosphoric acid catalyzed asymmetric bromination. Two asymmetric reactions (desymmetrization and kin...
Clinical Trials
Beta-2 Polymorphisms and Beta Receptor Selectivity
We hypothesize that b2 adrenergic polymorphisms affect b-receptor selectivity in patients with heart failure treated with either a b1-selective or a b-nonselective agent. b-2 polymorphisms...
Study of the Biological and Physical Manifestations of Spontaneous Uric Acid Kidney Stone Disease
This study has two aims: Aim 1: To determine the presence of accumulation of fat within cells and the functional consequences of this in the kidney by correlating kidney fat content with...
Impact of Oximetry on Hospitalization in Acute Bronchiolitis
To determine, in previously healthy infants 6 weeks to 12 months of age, diagnosed with acute bronchiolitis and monitored by hourly oximetry, if the probability of hospitalization within 7...
Neoadjuvant Zoledronic Acid in Patients With Resectable Pancreas Cancer
The overall purpose of this research is to evaluate the safety and side effects of zoledronic acid (also known as Zometa) in patients before they have surgery to remove the cancer.
Photodynamic therapy (PDT) is the selective destruction of abnormal cells through light activation of a photosensitiser in the presence of oxygen. These cells accumulate more photosensitis...
