Expression of A20 is reduced in pancreatic cancer tissues.
Summary of "Expression of A20 is reduced in pancreatic cancer tissues."
A20 protein plays essential roles in tumorigenesis, but its value for diagnosis of pancreatic cancer remains unclear. Our aim was to determine whether A20 is a potential biomarker for the diagnosis of pancreatic cancer. The pancreatic cancer tissue microarray contained pancreatic cancer tissues (n = 40) and normal tissues (n = 10) was immunohistochemically assessed for A20 expression. The association of A20 expression with the tumor grade, lymph node metastasis, age and gender in pancreatic cancer patients were estimated by ANOVA. Stronger staining of A20 was observed in the normal tissues compared with that in the pancreatic cancer tissues (P = 0.003). ANOVA analysis showed that the A20 expression was not deeply associated with tumor grade, gender, age or TNM stages. The results implied that low A20 expression is significantly associated with the pancreatic cancer behavior, but is not the sole determinant of pancreatic cancer progression.
Department of General Surgery, Tangdu Hospital of The Fourth Military Medical University, Xi'an, 710038, Shaanxi, China.
This article was published in the following journal.
Name: Journal of molecular histology
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22461193
- DOI: http://dx.doi.org/10.1007/s10735-012-9402-6
Medical and Biotech [MESH] Definitions
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Pancreatic Stellate Cells
Star-shaped, myofibroblast-like cells located in the periacinar, perivascular, and periductal regions of the EXOCRINE PANCREAS. They play a key role in the pathobiology of FIBROSIS; PANCREATITIS; and PANCREATIC CANCER.
A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
Peptides derived from proglucagon which is also the precursor of pancreatic GLUCAGON. Despite expression of proglucagon in multiple tissues, the major production site of glucagon-like peptides (GLPs) is the INTESTINAL L CELLS. GLPs include glucagon-like peptide 1, glucagon-like peptide 2, and the various truncated forms.
Extracts prepared from pancreatic tissue that may contain the pancreatic enzymes or other specific uncharacterized factors or proteins with specific activities. PANCREATIN is a specific extract containing digestive enzymes and used to treat pancreatic insufficiency.
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