Implications of the international society of urological pathology modified Gleason grading system.
Summary of "Implications of the international society of urological pathology modified Gleason grading system."
Context.-Histologic grading is the clinically most useful tissue-based predictor of prognosis for prostate cancer. Over the years, there has been a gradual shift in how the Gleason grading is applied in practice, with a general trend toward upgrading. A consensus conference was organized in 2005 by the International Society of Urological Pathology (ISUP) for standardizing both the perception of histologic patterns and how the grade information is compiled and reported. Objective.-To review the implications of the ISUP modified Gleason grading system. Data Sources.-Personal experience and review of the current literature. Conclusions.-The recommendations regarding pattern interpretation and reporting are summarized. The practical consequences of the ISUP modification of the Gleason grading are reported. The prognostic importance of the Gleason score, its reproducibility, and its preoperative assessment are discussed. Subsequent proposals for slight modifications to the ISUP grading system are described.
Affiliation
Journal Details
This article was published in the following journal.
Name: Archives of pathology & laboratory medicine
ISSN: 1543-2165
Pages: 426-34
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22458905
- DOI: http://dx.doi.org/10.5858/arpa.2011-0495-RA
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System established by the World Health Organization and the International Committee on Thrombosis and Hemostasis for monitoring and reporting blood coagulation tests. Under this system, results are standardized using the International Sensitivity Index for the particular test reagent/instrument combination used.
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