Advertisement

Topics

Plant-derived vaccines and other therapeutics produced in contained systems.

06:00 EDT 3rd August 2010 | BioPortfolio

Summary of "Plant-derived vaccines and other therapeutics produced in contained systems."

The use of contained plant systems for the production of biopharmaceuticals represents a powerful alternative to current methods, combining the benefits of whole-plant systems and cell cultures. In vitro contained production systems include plant cell suspensions, hairy root cultures, novel plants grown in contained conditions and microalgae. These systems show intrinsic advantages, such as control over growth conditions, production in compliance with good manufacturing practice and avoidance of political resistance to the release of genetically modified field crops. At present, one of the two plant-produced vaccine-related products that have gone all the way through production and regulatory hurdles derives from tobacco cell suspensions, and the second is a human therapeutic enzyme, which is expected to reach commercial development soon and derives from carrot suspension cells. In the future, several other products from contained systems are expected to reach the clinical trial stage.

Affiliation

Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), UTBIORAD, Laboratory of Biotechnology, CR Casaccia, Via Anguillarese 301, Rome, 00123, Italy.

Journal Details

This article was published in the following journal.

Name: Expert review of vaccines
ISSN: 1744-8395
Pages: 877-92

Links

DeepDyve research library

PubMed Articles [22424 Associated PubMed Articles listed on BioPortfolio]

Optimization of atrazine and imidacloprid removal from water using biochars: Designing single or multi-staged batch adsorption systems.

Contamination of surface and ground water by pesticides from agricultural runoff and industrial discharge is one of the main causes of aqueous contaminations world over. Biochar, agricultural waste de...

From discovery to licensure, the Adjuvant System story.

Adjuvants are substances added to vaccines to improve their immunogenicity. Used for more than 80 years, aluminum, the first adjuvant in human vaccines, proved insufficient to develop vaccines that c...

HPV vaccines: Global perspectives.

The discovery of HPV as the etiological factor for HPV-associated malignancies and disease has opened up several opportunities for prevention and therapy. Current commercially available HPV vaccines (...

Introduction to RNA Vaccines.

RNA vaccines are attractive, because they exhibit characteristics of subunit vaccines and live-attenuated vectors, including flexible production and induction of both humoral and cellular immunity. Wh...

Designer outer membrane vesicles as immunomodulatory systems - reprogramming bacteria for vaccine delivery.

Vaccines often require adjuvants to be effective. Traditional adjuvants, like alum, activate the immune response but in an uncontrolled way. Newer adjuvants help to direct the immune response in a mor...

Clinical Trials [3371 Associated Clinical Trials listed on BioPortfolio]

Impact of Ibis on Patients With Advanced COPD

The purpose of this research is to determine if Ibis™, a digital therapeutics solution developed by Senscio Systems, reduces the emergency room visits and hospitalizations of patients wi...

The Effects of Plant Bioactives on Platelet Function

Consumption of a diet rich in fruit and vegetables is associated with a reduced risk of cardiovascular disease and the protective effect may be due to polyphenolic compounds contained with...

Comparison of Safety, Tolerability and Immunogenicity of Influenza Vaccines in Adults and Elderly

The purpose of the study is to evaluate safety, tolerability and immunogenicity (in a subset) following a dose of a trivalent subunit influenza vaccine produced either in mammalian cells o...

The Influence of Dietary Plant Sterols and Plant Stanols on Cholesterol and Plant Sterol Levels in Atheromatous Plaques

This study aims to explore whether the increased supply of dietary plant sterols and plant stanols have any influence on serum levels of phytosterols and on consistency of carotid atheroma...

Efficacy Study of Two Influenza Vaccines and Placebo in Healthy Adult Subjects

The present study will evaluate clinical efficacy, safety, tolerability and immunogenicity of both Novartis Vaccines' cell-derived influenza vaccine and egg-derived influenza vaccine in he...

Medical and Biotech [MESH] Definitions

Vaccines or candidate vaccines derived from edible plants. Transgenic plants (PLANTS, TRANSGENIC) are used as recombinant protein production systems and the edible plant tissue functions as an oral vaccine.

Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.

Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.

Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.

Vaccines that are produced by using only the antigenic part of the disease causing organism. They often require a "booster" every few years to maintain their effectiveness.

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topic

GMO Crops
A genetically modified organism (GMO) is an organism whose genetic material has been altered using genetic engineering techniques. Organisms that have been genetically modified include micro-organisms such as bacteria and yeast, insects, plants, fish, an...


Searches Linking to this Article