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Inhibitory effect of curcumin on uterine leiomyoma cell proliferation.

06:00 EDT 3rd August 2010 | BioPortfolio

Summary of "Inhibitory effect of curcumin on uterine leiomyoma cell proliferation."

Objective. Uterine leiomyomas are the most common gynaecological benign tumour and greatly affect reproductive health and wellbeing. They are the predominant indication for hysterectomy in premenopausal women. Curcumin, a well-known component of turmeric, has been reported to prevent various diseases such as cancer, diabetes and obesity. Previous study reported that curcumin represses the proliferation of several tumour cells. However, there has not been a precise characterisation of the curcumin-induced inhibition of uterine leiomyoma cells. In this study, we investigated the inhibitory effect of curcumin on leiomyoma cells proliferation. Study design. Eker rat-derived uterine leiomyoma cell lines (ELT-3 cells) were used. Cell proliferation was assessed by counting the number of cells and MTS assay. The activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) was evaluated by luciferase assay. Results. We found that curcumin significantly inhibited ELT-3 cell proliferation. PPARgamma was expressed in ELT-3 cells and curcumin acted as a PPARgamma ligand. This inhibitory effect of curcumin was attenuated by the treatment of cells with PPARgamma antagonist. Conclusion. These experimental findings in vitro show that the inhibitory effect of curcumin on ELT-3 cell proliferation occurs through the activation of PPARgamma. Curcumin may be useful as an alternative therapy for uterine leiomyoma.

Affiliation

Center for Asian Traditional Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Journal Details

This article was published in the following journal.

Name: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
ISSN: 1473-0766
Pages:

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Medical and Biotech [MESH] Definitions

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A family of nucleotide diphosphate kinases that play a role in a variety of cellular signaling pathways that effect CELL DIFFERENTIATION; CELL PROLIFERATION; and APOPTOSIS. They are considered multifunctional proteins that interact with a variety of cellular proteins and have functions that are unrelated to their enzyme activity.

The decrease in the cell's ability to proliferate with the passing of time. Each cell is programmed for a certain number of cell divisions and at the end of that time proliferation halts. The cell enters a quiescent state after which it experiences CELL DEATH via the process of APOPTOSIS.

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