Preimplantation genetic diagnosis with HLA matching-a way to save a child.
Summary of "Preimplantation genetic diagnosis with HLA matching-a way to save a child."
Preimplantation genetic diagnosis can be used to establish a pregnancy with an embryo that is human leucocyte antigen (HLA) matched to a sibling having a hematological or immunological disease and needing a life-saving bone marrow transplantation. The ethical aspects of this procedure have been discussed intensively. The procedure applies where no unrelated HLA-matching donor is available or when transplantation from a HLA-matching sibling is considered a better solution. It is only offered in a limited number of centers in Europe since this is a challenging procedure. Where both HLA matching and diagnosis of a dominant disease is necessary, only a proportion of the embryos can be used, and the procedure is not always technically feasible. The clinical pregnancy rate per cycle started is much lower than following normal in-vitro fertilisation (IVF) due to a high cycle cancellation rate, but measured per transfer, the success rate is only somewhat lower.
Affiliation
1Fertility Clinic/Center for Preimplantation Genetic Diagnosis, Aarhus University Hospital, Aarhus, Denmark.
Journal Details
This article was published in the following journal.
Name: Acta obstetricia et gynecologica Scandinavica
ISSN: 1600-0412
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22524201
- DOI: http://dx.doi.org/10.1111/j.1600-0412.2012.01426.x
Medical and Biotech [MESH] Definitions
Preimplantation Diagnosis
Determination of the nature of a pathological condition or disease in the ovum, zygote, or blastocyst prior to implantation. CYTOGENETIC ANALYSIS is performed to determine the presence or absence of genetic disease.
Parenting
Performing the role of a parent by care-giving, nurturance, and protection of the child by a natural or substitute parent. The parent supports the child by exercising authority and through consistent, empathic, appropriate behavior in response to the child's needs. PARENTING differs from CHILD REARING in that in child rearing the emphasis is on the act of training or bringing up the children and the interaction between the parent and child, while parenting emphasizes the responsibility and qualities of exemplary behavior of the parent.
Child Psychiatry
The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders in children.
Child Rearing
The training or bringing-up of children by parents or parent-substitutes. It is used also for child rearing practices in different societies, at different economic levels, in different ethnic groups, etc. It differs from PARENTING in that in child rearing the emphasis is on the act of training or bringing up the child and the interaction between the parent and child, while parenting emphasizes the responsibility and qualities of exemplary behavior of the parent.
Recombination, Genetic
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
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