Time dependent effect on mortality of drug-eluting stents versus bare metal stents.
Summary of "Time dependent effect on mortality of drug-eluting stents versus bare metal stents."
Objective. The comparison of all-cause long-term mortality between the use of drug-eluting stents versus bare metal stents in patients treated with percutaneous coronary interventions. Design. Observational data from patients treated at Feiring Heart Clinic from 1999 until 2010 with a follow-up of survival at March 8, 2011. The survival was compared using Cox regression with ordinary covariates, propensity score used as covariate and 1:1 propensity score matching. Results. The analyses included 5690 patients treated solely with bare metal stents and 2916 with drug-eluting stents. During the study period (October 2002 to March 2011), 996 deaths were observed. Due to nonproportional hazard effect on mortality of drug-eluting stents compared to bare metal stents, a landmark analysis splitting time at 9 months was employed. All analyses indicated a significantly reduced mortality by drug-eluting stents in the first 9 months with hazard ratios ranging from 0.42 to 0.51 with no difference in mortality from 9 months to 8 years of follow-up. Conclusions. Short-term mortality was significantly reduced in the drug-eluting stent group compared to the bare metal stent group. A selection bias could not be ruled out as an explanation for this effect. No difference was observed in mortality after 9 months.
Affiliation
Feiring Heart Clinic , Feiring , Norway.
Journal Details
This article was published in the following journal.
Name: Scandinavian cardiovascular journal : SCJ
ISSN: 1651-2006
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22462392
- DOI: http://dx.doi.org/10.3109/14017431.2012.681308
Medical and Biotech [MESH] Definitions
Drug-eluting Stents
Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.
Drug-induced Liver Injury, Chronic
Liver disease lasting six months or more, caused by an adverse drug effect. The adverse effect may result from a direct toxic effect of a drug or metabolite, or an idiosyncratic response to a drug or metabolite.
Drug Partial Agonism
Drug agonism involving selective binding but reduced effect. This can result in some degree of DRUG ANTAGONISM.
Drug Tolerance
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
Drug Substitution
The practice of replacing one prescribed drug with another that is expected to have the same clinical or psychological effect.
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