Time dependent effect on mortality of drug-eluting stents versus bare metal stents.
Summary of "Time dependent effect on mortality of drug-eluting stents versus bare metal stents."
Objective. The comparison of all-cause long-term mortality between the use of drug-eluting stents versus bare metal stents in patients treated with percutaneous coronary interventions. Design. Observational data from patients treated at Feiring Heart Clinic from 1999 until 2010 with a follow-up of survival at March 8, 2011. The survival was compared using Cox regression with ordinary covariates, propensity score used as covariate and 1:1 propensity score matching. Results. The analyses included 5690 patients treated solely with bare metal stents and 2916 with drug-eluting stents. During the study period (October 2002 to March 2011), 996 deaths were observed. Due to nonproportional hazard effect on mortality of drug-eluting stents compared to bare metal stents, a landmark analysis splitting time at 9 months was employed. All analyses indicated a significantly reduced mortality by drug-eluting stents in the first 9 months with hazard ratios ranging from 0.42 to 0.51 with no difference in mortality from 9 months to 8 years of follow-up. Conclusions. Short-term mortality was significantly reduced in the drug-eluting stent group compared to the bare metal stent group. A selection bias could not be ruled out as an explanation for this effect. No difference was observed in mortality after 9 months.
Feiring Heart Clinic , Feiring , Norway.
This article was published in the following journal.
Name: Scandinavian cardiovascular journal : SCJ
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22462392
- DOI: http://dx.doi.org/10.3109/14017431.2012.681308
Medical and Biotech [MESH] Definitions
Stents that are covered with materials that are embedded with chemicals that are gradually released into the surrounding milieu.
Drug-induced Liver Injury, Chronic
Liver disease lasting six months or more, caused by an adverse drug effect. The adverse effect may result from a direct toxic effect of a drug or metabolite, or an idiosyncratic response to a drug or metabolite.
Drug Partial Agonism
Drug agonism involving selective binding but reduced effect. This can result in some degree of DRUG ANTAGONISM.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
The practice of replacing one prescribed drug with another that is expected to have the same clinical or psychological effect.
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