Microwave denture disinfection versus nystatin in treating patients with well-controlled type 2 diabetes and denture stomatitis: a randomized clinical trial.
Summary of "Microwave denture disinfection versus nystatin in treating patients with well-controlled type 2 diabetes and denture stomatitis: a randomized clinical trial."
Purpose: The aim of this randomized clinical trial was to compare the effectiveness of microwave denture disinfection and nystatin in the treatment of well-controlled type 2 diabetic patients with denture stomatitis in terms of microbiologic and clinical outcomes. Materials and Method: Diabetic patients wearing maxillary complete dentures with denture stomatitis (n = 40) were divided into two groups: NYS (patients treated with topical nystatin 4 times/day for 14 days) and MW (patients who had their dentures microwaved [650 W for 3 minutes] 3 times/week for 14 days). Mycologic samples were taken from the palates and dentures of the patients for quantification and identification of Candida, and standardized photographs of the palates were taken for clinical analysis. Evaluations were repeated at baseline, the end of treatment (day 14), and throughout follow-up (days 30, 60, and 90). Microbiologic data were evaluated by analysis of variance using a random effects statistical model, Tukey post hoc test, and chi-square test (α = .05). Clinical resuts were analyzed using Mann-Whitney and Fisher exact tests (α = .05). Results: Both treatments were considered successful in reducing the clinical signs of denture stomatitis and significantly reduced the values of colony-forming units/mL from the palates and dentures at days 14 and 30. In addition, 40% of treated patients were cured by the end of treatment. No significant differences in the microbiologic and clinical outcomes were revealed between the two groups (P > .05). C albicans was the most predominant species isolated (P < .01), followed by C tropicalis and C glabrata. Conclusion: Denture microwave disinfection was as effective as nystatin for the treatment of diabetic patients with denture stomatitis.
Affiliation
Journal Details
This article was published in the following journal.
Name: The International journal of prosthodontics
ISSN: 0893-2174
Pages: 232-44
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22545252
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Nystatin
Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.
Denture Rebasing
The process of refitting a denture by replacing the denture base material without changing the occlusal relations of the teeth. Rebasing may include adding to the denture base to compensate for resorptive changes to subjacent structures.
Denture Liners
Material applied to the tissue side of a denture to provide a soft lining to the parts of a denture coming in contact with soft tissue. It cushions contact of the denture with the tissues.
Denture, Complete, Immediate
A complete denture constructed for replacement of natural teeth immediately after their removal. It does not fit the mouth perfectly and is intended only for functional and cosmetic purposes during the healing process after total extraction. It is to be replaced by the fitted permanent denture.
Food Packaging
Containers, packaging, and packaging materials for processed and raw foods and beverages. It includes packaging intended to be used for storage and also used for preparation of foods such as microwave food containers versus COOKING AND EATING UTENSILS. Packaging materials may be intended for food contact or designated non-contact, for example, shipping containers. FOOD LABELING is also available.
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