What does it take to stick around?: Molecular insights into biofilm formation by uropathogenic Escherichia coli.
Summary of "What does it take to stick around?: Molecular insights into biofilm formation by uropathogenic Escherichia coli."
Existence in the biofilm state lends bacteria the opportunity to enjoy, at least for a finite amount of time, the benefits of a multicellular entity. The order of events leading to biofilm formation and disassembly has been the topic of interest for numerous studies, aiming to identify factors and mechanisms that underlie this dynamic developmental process. Of particular import is research leveraged at delineating biofilm formation by medically relevant microorganisms, as prevention or eradication of biofilm from medical devices and from within the host pose a serious challenge in the healthcare setting. Recent research describes how a transcriptional regulator modulates biofilm formation in uropathogenic Escherichia coli (UPEC) by affecting the expression of the type 1 adhesive organelles in response to extracellular signals.
Affiliation
Department of Molecular Microbiology and Center for Womens' Infectious Disease Research; Washington University in Saint Louis; Saint Louis, MO USA.
Journal Details
This article was published in the following journal.
Name: Virulence
ISSN: 2150-5608
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22546905
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Adhesiveness
A property of the surface of an object that makes it stick to another surface.
Agglutinins
Substances, usually of biological origin, that cause cells or other organic particles to aggregate and stick to each other. They include those ANTIBODIES which cause aggregation or agglutination of particulate or insoluble ANTIGENS.
Molecular Epidemiology
The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.
Evolution, Molecular
Evolution at the molecular level of DNA sequences and proteins. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Molecular Sequence Annotation
The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.
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