Increased hydrophobicity in Malassezia species correlates with increased proinflammatory cytokine expression in human keratinocytes.
Summary of "Increased hydrophobicity in Malassezia species correlates with increased proinflammatory cytokine expression in human keratinocytes."
Malassezia cells stimulate cytokine production by keratinocytes, although this ability differs among Malassezia species for unknown reasons. The aim of this study was to clarify the factors determining the ability to induce cytokine production by human keratinocytes in response to Malassezia species. M. furfur NBRC 0656, M. sympodialis CBS 7222, M. dermatis JCM 11348, M. globosa CBS 7966, M. restricta CBS 7877, and three strains each of M. globosa, M. restricta, M. dermatis, M. sympodialis, and M. furfur maintained under various culture conditions were used. Normal human epidermal keratinocytes (NHEKs) (1 × 10(5) cells) and the Malassezia species (1 × 10(6) cells) were co-cultured, and IL-1α, IL-6, and IL-8 mRNA levels were determined. Moreover, the hydrophobicity and β-1,3-glucan expression at the surface of Malassezia cells were analyzed. The ability of Malassezia cells to trigger the mRNA expression of proinflammatory cytokines in NHEKs differed with the species and conditions and was dependent upon the hydrophobicity of Malassezia cells not β-1,3-glucan expression.
* Department of Dermatology, Fujita Health University School of Medicine , Toyoake, Aichi , Japan.
This article was published in the following journal.
Name: Medical mycology : official publication of the International Society for Human and Animal Mycology
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22548238
- DOI: http://dx.doi.org/10.3109/13693786.2012.678019
Medical and Biotech [MESH] Definitions
A mitosporic fungal genus that causes a variety of skin disorders. Malassezia furfur (Pityrosporum orbiculare) causes TINEA VERSICOLOR.
The property of substances of reduced affinity for or repulsion of water.
A proinflammatory cytokine produced primarily by T-LYMPHOCYTES or their precursors. Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.
Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascular permeability and help initiate proinflammatory and immune reactions at the site of injury.
Eosinophil Granule Proteins
Proteins found in EOSINOPHIL granules. They are primarily basic proteins that play a role in host defense and the proinflammatory actions of activated eosinophils.
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