Treatment of Melasma With Oral Administration of Tranexamic Acid.
Summary of "Treatment of Melasma With Oral Administration of Tranexamic Acid."
BACKGROUND:
Melasma is a common pigmentary disorder among Asian women. The available therapies such as bleaching agents, chemical peeling, laser, and intense pulsed light are not satisfactory or safe. In the search to find a new treatment therapy for melasma, oral administration of tranexamic acid (TA) was studied clinically in Chinese patients.
METHODS:
The study enrolled 74 patients. Tranexamic acid tablets were prescribed at a dosage of 250 mg twice daily for a therapeutic period of 6 months. All the patients were followed up for more than 6 months after the treatment. The effects of treatment were evaluated by two physicians independently and by the patient based on improvement of pigmentation and reduction in melasma size. These were graded into four levels: excellent, good, fair, and poor.
RESULTS:
After 6 months of treatment, the effects were graded as follows: excellent (10.8 %, 8/74), good (54 %, 40/74), fair (31.1 %, 23/74), and poor (4.1 %, 3/74). Side effects of TA such as gastrointestinal discomfort (5.4 %) and hypomenorrhea (8.1 %) were observed, but no severe complications were found. The recurrence of melasma was observed in seven cases (9.5 %).
CONCLUSIONS:
Oral administration of TA is an effective and safe therapy for the treatment of melasma. LEVEL OF EVIDENCE
II:
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors at www.springer.com/00266.
Affiliation
Department of Plastic and Reconstructive Surgery, Zhejiang Provincial People's Hospital, #158 Shangtang Road, Hangzhou, 310014, People's Republic of China, sufanwu@hotmail.com.
Journal Details
This article was published in the following journal.
Name: Aesthetic plastic surgery
ISSN: 1432-5241
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22552446
- DOI: http://dx.doi.org/10.1007/s00266-012-9899-9
Medical and Biotech [MESH] Definitions
Formiminoglutamic Acid
Measurement of this acid in the urine after oral administration of histidine provides the basis for the diagnostic test of folic acid deficiency and of megaloblastic anemia of pregnancy.
Tranexamic Acid
Antifibrinolytic hemostatic used in severe hemorrhage.
Amoxicillin
A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Surgery, Oral
A dental specialty concerned with the diagnosis and surgical treatment of disease, injuries, and defects of the human oral and maxillofacial region.
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