Photoinduced reactivity of Doxorubicin: catalysis and degradation.
Summary of "Photoinduced reactivity of Doxorubicin: catalysis and degradation."
Doxorubicin exhibits unusual photoreactivity in aqueous solutions. Our data show that there are two distinct photoreactive pathways for doxorubicin. One is a two-step process that leads to the formation of 3-methoxysalicylic acid, a stable degradation product. The other pathway is a photoreduction of doxorubicin to form the corresponding dihydroquinone, which undergoes spontaneous oxidation mediated by dissolved oxygen to recover doxorubicin with the formation of hydrogen peroxide. Our data account for the known nonlinear dependence of doxorubicin fluorescence intensity on concentration.
Department of Chemistry, University of Warsaw , Pasteura 1, Warsaw 02-093 Poland.
This article was published in the following journal.
Name: The journal of physical chemistry. A
Medical and Biotech [MESH] Definitions
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Peptide hydrolases that contain at the active site a SERINE residue involved in catalysis.
Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.
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