Modulation of proteasome machinery by natural and synthetic analogues of the marine bioactive compound petrosaspongiolide m.
Summary of "Modulation of proteasome machinery by natural and synthetic analogues of the marine bioactive compound petrosaspongiolide m."
Natural or synthetic? Several petrosaspongiolide M natural and synthetic analogues have been tested as proteasome inhibitors and apoptosis modulators. The natural petrosaspongiolide M congeners gave a consistent decrease in activity. Among the synthetic analogues, the introduction of the benzothiophene ring resulted in a bioequivalent alternative of the petrosaspongiolide M terpenoid system.
Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte don Melillo, 84084 Fisciano (Italy).
This article was published in the following journal.
Name: Chembiochem : a European journal of chemical biology
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22438326
- DOI: http://dx.doi.org/10.1002/cbic.201200113
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