Tianeptine reduces morphine antinociceptive tolerance and physical dependence.
Summary of "Tianeptine reduces morphine antinociceptive tolerance and physical dependence."
Long-term use of morphine can cause neuronal dystrophic changes in specific areas of brain. These changes may underlie the mechanism for developing morphine antinociceptive tolerance and physical dependence. We evaluated the effect of tianeptine, an antidepressant with prominent neuroprotective and neuroplastic properties, on the development of morphine antinociceptive tolerance and physical dependence. Male C57BL/6 mice were rendered tolerant to or dependent on morphine by subcutaneously injecting them with morphine (10 mg/kg) and intraperitoneally with saline or tianeptine (1, 3, or 5 mg/kg) twice daily for 6 days. The mice were given a daily tail-flick test 1 h after the first morphine injection to evaluate the development of their tolerance to morphine antinociception. To evaluate their physical dependence on morphine, 3 h after the final morphine injection on day 6, naloxone-HCl-precipitated (2 mg/kg, intraperitoneally) withdrawal symptoms were counted for 30 min, and body weight was checked 1 h after the naloxone injection. Tianeptine per se produced no antinociception, neither it modified the antinociception produced by morphine, nor it evoked the behavioral responses different from those in the saline controls. The combination of tianeptine with morphine significantly reduced the development of morphine antinociceptive tolerance and suppressed the incidence of naloxone-precipitated withdrawal symptoms. We conclude that tianeptine is an effective inhibitor of morphine-induced antinociceptive tolerance and physical dependence in mice. Our results would imply that comedication with tianeptine and morphine might benefit those who need long-term morphine treatment.
Affiliation
Departments of aAnesthesiology bMedical Research, Chi Mei Medical Center cDepartment of Recreation and Health-Care Management, Chia Nan University of Pharmacy and Science, Tainan dGraduate Institute of Medical Sciences eDepartment of Anesthesiology, Tri-S
Journal Details
This article was published in the following journal.
Name: Behavioural pharmacology
ISSN: 1473-5849
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20679893
- DOI: http://dx.doi.org/10.1097/FBP.0b013e32833db7d4
Medical and Biotech [MESH] Definitions
Morphine Dependence
Strong dependence, both physiological and emotional, upon morphine.
Meperidine
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Methadone
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
Radiation Tolerance
The ability of some cells or tissues to withstand ionizing radiation without serious injury. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.
Alcoholics
Persons who have a history of physical or psychological dependence on ETHANOL.
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