Sleep timing may modulate the effect of sleep loss on testosterone.
Summary of "Sleep timing may modulate the effect of sleep loss on testosterone."
BACKGROUND:
Sleep loss has been shown to reduce secretory activity of the pituitary-gonadal axis in men, but the determinants of this effect are unknown.
OBJECTIVE:
To discriminate the effects of sleep duration and sleep timing on serum concentrations of luteinizing hormone (LH), testosterone (T), and prolactin (PRL).
METHODS:
Fifteen young, healthy men (27.1 ± 1.3 years; BMI 22.9 ± 0.3 kg/m(2) ) were examined in a condition of sleep time restriction to 4 h (bedtime 0245h-0700h) for two consecutive nights and in a control condition of 8 h regular sleep (bedtime 2245h-0700h). After the second night, serum concentrations of LH, T, and PRL were monitored over a 15 h period. In addition, these hormones were measured in serum samples obtained in a further experiment in 8 healthy men (24.5 ± 1.1 years; BMI 23.7 ± 0.6 kg/m(2) ) in the morning after one night of total sleep deprivation, of 4.5 h sleep (bedtime 2230h-0330h), and of regular 7 h sleep (bedtime 2230h-0600h).
RESULTS:
Serum LH, T, and PRL concentrations showed characteristic diurnal variations across the 15-h period without any differences between the 4 h and 8 h sleep conditions. However, total sleep deprivation and 4.5 h of sleep restricted to the first night-half markedly decreased morning T and PRL concentrations (both P ≤ 0.05).
CONCLUSION:
Collectively, our data suggest that the effect of sleep restriction on pituitary-gonadal secretory activity may be modulated by sleep timing. While sleep loss in the early part of the night does not affect T and PRL, early awakening and wakefulness during the second part of the night reduces morning circulating T and PRL concentrations. © 2012 Blackwell Publishing Ltd.
Affiliation
Departments of Internal Medicine, University of Luebeck, D-23538, Luebeck, Germany.
Journal Details
This article was published in the following journal.
Name: Clinical endocrinology
ISSN: 1365-2265
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22568763
- DOI: http://dx.doi.org/10.1111/j.1365-2265.2012.04419.x
Medical and Biotech [MESH] Definitions
Sleep Stages
Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.
Sleep Disorders, Intrinsic
Dyssomnias (i.e., insomnias or hypersomnias) associated with dysfunction of internal sleep mechanisms or secondary to a sleep-related medical disorder (e.g., sleep apnea, post-traumatic sleep disorders, etc.). (From Thorpy, Sleep Disorders Medicine, 1994, p187)
Parasomnias
Movements or behaviors associated with sleep, sleep stages, or partial arousals from sleep that may impair sleep maintenance. Parasomnias are generally divided into four groups: arousal disorders, sleep-wake transition disorders, parasomnias of REM sleep, and nonspecific parasomnias. (From Thorpy, Sleep Disorders Medicine, 1994, p191)
Sleep Apnea, Central
A condition associated with multiple episodes of sleep apnea which are distinguished from obstructive sleep apnea (SLEEP APNEA, OBSTRUCTIVE) by the complete cessation of efforts to breathe. This disorder is associated with dysfunction of central nervous system centers that regulate respiration. This condition may be idiopathic (primary) or associated with lower brain stem lesions; chronic obstructive pulmonary disease (LUNG DISEASES, OBSTRUCTIVE); HEART FAILURE, CONGESTIVE; medication effect; and other conditions. Sleep maintenance is impaired, resulting in daytime hypersomnolence. Primary central sleep apnea is frequently associated with obstructive sleep apnea. When both forms are present the condition is referred to as mixed sleep apnea (see SLEEP APNEA SYNDROMES). (Adams et al., Principles of Neurology, 6th ed, p395; Neurol Clin 1996;14(3):611-28)
Sleep Deprivation
The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.
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