Triterpenoid α-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage.
Summary of "Triterpenoid α-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage."
Rhaponticum carthamoides plants ("maral root") are widely used in Siberian folk medicine. The present study reports for the first time the presence of pentacyclic terpenoid, α-amyrin, in methanol extract from leaves of this plant. α-Amyrin induced proliferation of human keratinocytes (HaCaT) by about 18% while other extract components were ineffective. A panel of biochemical and cell-based assays testing the antioxidative and cytoprotective activites of α-amyrin indicated no antioxidative activity of this compound. α-Amyrin did not protect HaCaT cells against the damage caused by UVB radiation.
Affiliation
Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark and Department of Plant Protection and Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdansk, Poland.
Journal Details
This article was published in the following journal.
Name: Acta biochimica Polonica
ISSN: 1734-154X
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22577623
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
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Cytokine that stimulates the proliferation of T-LYMPHOCYTES and shares biological activities with IL-2. IL-15 also can induce proliferation and differentiation of B-LYMPHOCYTES.
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United States Environmental Protection Agency
An agency in the Executive Branch of the Federal Government. It was created as an independent regulatory agency responsible for the implementation of federal laws designed to protect the environment. Its mission is to protect human health and the ENVIRONMENT.
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