Dopamine receptors D1 and D2 are related to observed maternal behavior.
Summary of "Dopamine receptors D1 and D2 are related to observed maternal behavior."
The dopamine pathway and especially the dopamine receptors 1 and 2 (DRD1 and DRD2) are implicated in the regulation of mothering in rats. Evidence for this in humans is lacking. Here we show that genetic variation in both DRD1 and DRD2 genes in a sample of 187 Caucasian mothers predicts variation in distinct maternal behaviours during a 30-minute mother-infant interaction at 6 months postpartum. Two DRD1 single nucleotide polymorphisms (SNPs rs265981 and rs686) significantly associated with maternal orienting away from the infant (p=0.002 and p=0.003, respectively), as did DRD1 haplotypes (p=0.03). Two DRD2 SNPs (rs1799732 and rs6277) significantly associated with maternal infant-directed vocalizing (p=0.001 and p=0.04, respectively), as did DRD2 haplotypes (p=0.01). We present evidence for heterosis in DRD1 where heterozygote mothers orient away from their infants significantly less than either homozygote group. Our findings provide important evidence that genetic variation in receptors critical for mothering in non-human species also affect human maternal behaviours. The findings also highlight the importance of exploring multiple dimensions of the complex human mothering phenotype.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada Department of Psychology, University of Toronto Mississauga, Mississauga, ON, Canada Institute for Human Development, University of Toronto, ON, Canada Sackler Program for Epigenetic
This article was published in the following journal.
Name: Genes, brain, and behavior
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22574669
- DOI: http://dx.doi.org/10.1111/j.1601-183X.2012.00804.x
Medical and Biotech [MESH] Definitions
Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.
Receptors, Dopamine D5
A subtype of dopamine D1 receptors that has higher affinity for DOPAMINE and differentially couples to GTP-BINDING PROTEINS.
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Receptors, Dopamine D2
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLATE CYCLASE.
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