Dopamine receptors D1 and D2 are related to observed maternal behavior.
Summary of "Dopamine receptors D1 and D2 are related to observed maternal behavior."
The dopamine pathway and especially the dopamine receptors 1 and 2 (DRD1 and DRD2) are implicated in the regulation of mothering in rats. Evidence for this in humans is lacking. Here we show that genetic variation in both DRD1 and DRD2 genes in a sample of 187 Caucasian mothers predicts variation in distinct maternal behaviours during a 30-minute mother-infant interaction at 6 months postpartum. Two DRD1 single nucleotide polymorphisms (SNPs rs265981 and rs686) significantly associated with maternal orienting away from the infant (p=0.002 and p=0.003, respectively), as did DRD1 haplotypes (p=0.03). Two DRD2 SNPs (rs1799732 and rs6277) significantly associated with maternal infant-directed vocalizing (p=0.001 and p=0.04, respectively), as did DRD2 haplotypes (p=0.01). We present evidence for heterosis in DRD1 where heterozygote mothers orient away from their infants significantly less than either homozygote group. Our findings provide important evidence that genetic variation in receptors critical for mothering in non-human species also affect human maternal behaviours. The findings also highlight the importance of exploring multiple dimensions of the complex human mothering phenotype.
Affiliation
Institute of Medical Science, University of Toronto, Toronto, ON, Canada Department of Psychology, University of Toronto Mississauga, Mississauga, ON, Canada Institute for Human Development, University of Toronto, ON, Canada Sackler Program for Epigenetic
Journal Details
This article was published in the following journal.
Name: Genes, brain, and behavior
ISSN: 1601-183X
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22574669
- DOI: http://dx.doi.org/10.1111/j.1601-183X.2012.00804.x
Medical and Biotech [MESH] Definitions
Receptors, Dopamine
Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.
Receptors, Dopamine D5
A subtype of dopamine D1 receptors that has higher affinity for DOPAMINE and differentially couples to GTP-BINDING PROTEINS.
Dopamine Antagonists
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Dopamine
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Receptors, Dopamine D2
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLATE CYCLASE.
PubMed Articles
Accumbal dopamine plays an important role in physiological responses and diseases such as schizophrenia, Parkinson's disease, and depression. Since the nucleus accumbens contains different neurotransm...
Olfactory bulbectomy (OBX) induces behavioral, physiological, and neurochemical alterations resembling clinical depression and is widely used as an animal model of depression. It has been reported tha...
The present study examined the roles of dopamine and D(1)- and D(2)-like dopamine receptors in ventrolateral orbital cortex (VLO)-evoked antinociception in rats with persistent inflammatory pain. Foll...
To clarify the mechanisms by which compound 48/80 (C48/80) induces scratching behavior, the involvement of dopamine D(1) receptors was investigated. The intracisternal (i.t.) administration of SCH2339...
Background/Aims: In unilaterally dopamine-depleted rats, repeated treatment with dopamine agonists sensitizes contralateral rotational behavior. Since A2a adenosine receptors are co-localized with D2...
Clinical Trials
Brain, Obesity, Dopamine and You Study
Central dopamine is thought to play a significant role in obesity. In support of this idea, animal studies and one human positron emission tomography (PET) study have found reduced postsyn...
PET Imaging Study on Occupancy of Dopamine D2 Receptors and Genotypes After Bupropion Administration
Bupropion has different effects on D2 dopamine receptors according to genotype.
Tips for Infant and Parent Sleep (TIPS)
Infant and maternal sleep in the postpartum are related, and influenced by the mother's understanding of infant sleep behavior, the environmental and social cues for sleep presented to the...
Dopamine and Insulin Resistance
Obese individuals have fewer striatal dopamine type 2 receptors (DRD2) than normal weight individuals. Lower DRD2 levels are associated with addiction and a decreased sense of pleasure....
Trial of the Impact of Vitamin A on Maternal Mortality
Main objectives: To evaluate the impact of weekly vitamin A supplementation (VAS) to women of reproductive age (15-45 years) on maternal mortality in rural Ghana, and to compare this with...
