The prevalence of endometrial hyperplasia and endometrial cancer in women with polycystic ovary syndrome or hyperandrogenism.
Summary of "The prevalence of endometrial hyperplasia and endometrial cancer in women with polycystic ovary syndrome or hyperandrogenism."
Objective. Polycystic ovary syndrome may be associated with an increased risk of endometrial hyperplasia and endometrial cancer, but substantial evidence remains to be established. We investigated the prevalence of endometrial hyperplasia and endometrial cancer in a well-characterized group of women with polycystic ovary syndrome and/or clinical/biochemical hyperandrogenism. Design. Retrospective observational trans-sectional study. Setting. Out-patient clinic at the Departments of Endocrinology and Gynecology, Odense University Hospital, Denmark. Population. Nine hundred and sixty three premenopausal women consecutively referred with the diagnoses polycystic ovary syndrome and/or hirsutism during 1997-2008. Methods. All women underwent a standardized evaluation program. In 2011, The Danish Data Bank of Pathology was used to identify patients with endometrial histology diagnoses (year range of diagnosis 1982-2011). Main outcome measures. Histology diagnoses, demographic variables. Results. Endometrial hyperplasia was diagnosed in 10 (1.0%) women and endometrial cancer in 1 (0.1%) woman. The median body mass index in the cases was 30.6 kg/m(2) compared to 26.8 kg/m(2) in the total cohort. There were no differences between the cases and total cohort in terms of individual Rotterdam Criteria. In Denmark, 70 yearly cases of endometrial cancer are diagnosed in women 40-55 years corresponding to a prevalence of 0.4% in the corresponding period. Conclusion. The results of the present study do not suggest a higher prevalence of endometrial cancer in women with polycystic ovary syndrome and/or clinical/biochemical hyperandrogenism compared to the general population.
Affiliation
University of Southern Denmark, Odense, Department of Endocrinology, Odense University Hospital, Odense, Department of Pathology, Odense University Hospital, Odense, Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark.
Journal Details
This article was published in the following journal.
Name: Acta obstetricia et gynecologica Scandinavica
ISSN: 1600-0412
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22583042
- DOI: http://dx.doi.org/10.1111/j.1600-0412.2012.01458.x
Medical and Biotech [MESH] Definitions
Endometrial Hyperplasia
Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant.
Endometrial Stromal Tumors
Neoplasms of the endometrial stroma that sometimes involve the MYOMETRIUM. These tumors contain cells that may closely or remotely resemble the normal stromal cells. Endometrial stromal neoplasms are divided into three categories: (1) benign stromal nodules; (2) low-grade stromal sarcoma, or endolymphatic stromal myosis; and (3) malignant endometrial stromal sarcoma (SARCOMA, ENDOMETRIAL STROMAL).
Sarcoma, Endometrial Stromal
A highly malignant subset of neoplasms arising from the endometrial stroma. Tumors in this group infiltrate the stroma with a wide range of atypia cells and numerous mitoses. They are capable of widespread metastases (NEOPLASM METASTASIS).
Thecoma
A gonadal stromal neoplasm composed only of THECA CELLS, occurring mostly in the postmenopausal OVARY. It is filled with lipid-containing spindle cells and produces ESTROGENS that can lead to ENDOMETRIAL HYPERPLASIA; UTERINE HEMORRHAGE; or other malignancies in postmenopausal women and sexual precocity in girls. When tumors containing theca cells also contain FIBROBLASTS, they are identified as thecoma-fibroma tumors with less active hormone production.
Hamartoma Syndrome, Multiple
A hereditary disease characterized by multiple ectodermal, mesodermal, and endodermal nevoid and neoplastic anomalies. Facial trichilemmomas and papillomatous papules of the oral mucosa are the most characteristic lesions. Individuals with this syndrome have a high risk of BREAST CANCER; THYROID CANCER; and ENDOMETRIAL CANCER. This syndrome is associated with mutations in the gene for PTEN PHOSPHATASE.
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