A Pathogenic Role of Macrophages on intradermal infection of Methicillin-Resistant Staphylococcus aureus in Thermally Injured Mice.
Summary of "A Pathogenic Role of Macrophages on intradermal infection of Methicillin-Resistant Staphylococcus aureus in Thermally Injured Mice."
Intradermal infection of MRSA in burn mice was pathogenically analyzed. An abscess was formed in normal mice intradermally infected with 10(8) CFU/mouse of MRSA, and all of these mice survived after the infection; however, abscess formation was not demonstrated in burn mice similarly exposed to the pathogen, and all of these mice died within 5 days of infection. In burn mice, MRSA infected at the burn-site intradermal tissues spread quickly throughout the whole body, while in normal mice the pathogen remained localized at the infection site. M isolated from the infection site tissue of normal mice produced IL-12 but not IL-10 and were characterized as M1M. These M1M were not isolated from the infection site tissue of burn mice. When normal mouse infection site tissue M were adoptively transferred to burn mice at the MRSA infection site, an abscess formed, and the infection did not develop into sepsis. In contrast, an abscess did not form and sepsis developed in normal mice that were inoculated with burn mouse infection site tissue M. These M produced IL-10 but not IL-12 and were characterized as M2M. These results indicate that abscess formation is a major host resistance mechanism against MRSA intradermal infection. M1M in the tissues surrounding the infection site play a pivotal role in abscess formation; however, the abscess is not formed in burn mice where M2M predominate. M2M have been described as inhibitor cells for M conversion from resident M to M1M.
Affiliation
Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas; and Shriners Hospitals for Children, Galveston, Texas.
Journal Details
This article was published in the following journal.
Name: Infection and immunity
ISSN: 1098-5522
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20679444
- DOI: http://dx.doi.org/10.1128/IAI.00642-10
Medical and Biotech [MESH] Definitions
Methicillin-resistant Staphylococcus Aureus
A strain of Staphylococcus aureus that is non-susceptible to the action of METHICILLIN. The mechanism of resistance usually involves modification of normal or the presence of acquired PENICILLIN BINDING PROTEINS.
Staphylococcus Hominis
A species of STAPHYLOCOCCUS similar to STAPHYLOCOCCUS HAEMOLYTICUS, but containing different esterases. The subspecies Staphylococcus hominis novobiosepticus is highly virulent and novobiocin resistant.
Methicillin
One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
Methicillin Resistance
Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.
Staphylococcus Haemolyticus
A species of STAPHYLOCOCCUS found on the skin of humans (and non-human primates), often causing hospital-acquired infections (CROSS INFECTION).
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