Accuracy of intraocular lens power calculations in eyes with axial length <22.00mm.
Summary of "Accuracy of intraocular lens power calculations in eyes with axial length <22.00mm."
Background:   To assess the accuracy of Haigis, Holladay 1, Hoffer Q and SRK/T formulae in eyes with axial length of <22.00mm before and after lens constant adjustment for short eyes. Design:  Retrospective comparative analysis. Participants:   163 eyes of 97 patients undergoing phacoemulsification and IOL implantation. Methods:   Ocular biometry was performed using IOLMaster laser interferometry. Predicted refractive outcomes before and after lens constant adjustment were compared to actual refractive outcomes. Main Outcome Measures:   Mean prediction (ME) and mean absolute errors (MAE) Results:   Mean preoperative spherical equivalent was +5.44D ±1.97D. Mean axial length was 21.20mm ±0.60mm. Using standard IOL constants the MAE for Hoffer Q (0.62D, ±0.52D) and Holladay 1 (0.66D ±0.52D) were significantly lower than SRK/T (MAE 0.91D ±0.64D; P=<0.0005 and P=0.001 respectively), but not Haigis (MAE 0.82D ±0.83D, P=0.071 and 0.22 respectively). MAEs for all formulae were significantly reduced by IOL constant adjustment (all P=<0.001) and following this there was no statistically significant difference in MAEs between formulae (range 0.50-0.57D, P=0.57). Increasing MAE was significantly associated with reducing axial length and increasing IOL power for all formulae. For bilateral cases, prediction errors between eyes were significantly correlated across all formulae (all P=<0.0001) and explained 32-42% of the variance in prediction error between eyes. Conclusions:   Prediction of postoperative refraction in patients with short axial lengths is challenging and at the limit of current, popular IOL formulae. There is now a clear need for prospective studies to assess 4(th) generation IOL formulae such as Holladay 2 or Olsen in small eyes. © 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.
Affiliation
UCL Institute of Ophthalmology, London, UK. Moorfields Eye Hospital, London, UK NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London, UK.
Journal Details
This article was published in the following journal.
Name: Clinical & experimental ophthalmology
ISSN: 1442-9071
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22594574
- DOI: http://dx.doi.org/10.1111/j.1442-9071.2012.02810.x
Medical and Biotech [MESH] Definitions
Lens Implantation, Intraocular
Insertion of an artificial lens to replace the natural CRYSTALLINE LENS after CATARACT EXTRACTION or to supplement the natural lens which is left in place.
Phakic Intraocular Lenses
Lenses, generally made of plastic or silicone, that are implanted into the eye in front of the natural EYE LENS, by the IRIS, to improve VISION, OCULAR. These intraocular lenses are used to supplement the natural lens instead of replacing it.
Drug Dosage Calculations
Math calculations done for preparing appropriate doses of medicines, taking into account conversions of WEIGHTS AND MEASURES. Mistakes are one of the sources of MEDICATION ERRORS.
Alpha-crystallins
A subclass of crystallins that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits.
Pseudophakia
Presence of an intraocular lens after cataract extraction.
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