Opening a New GATAway for Treating KRAS-Driven Lung Tumors.
Summary of "Opening a New GATAway for Treating KRAS-Driven Lung Tumors."
In a recent issue of Cell, Kumar and colleagues uncovered a synthetic lethal interaction between oncogenic KRAS and the transcription factor GATA2 in non-small cell lung carcinoma. Pharmacological inhibition of GATA2-mediated pathways with bortezomib and fasudil results in dramatic tumor inhibition. These observations unveil new armamentaria to fight this deadly disease.
Affiliation
Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), E-28029 Madrid, Spain.
Journal Details
This article was published in the following journal.
Name: Cancer cell
ISSN: 1878-3686
Pages: 598-600
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22624710
- DOI: http://dx.doi.org/10.1016/j.ccr.2012.04.032
Medical and Biotech [MESH] Definitions
Lung Neoplasms
Tumors or cancer of the LUNG.
Pulmonary Atelectasis
Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.
Nitrosomethylurethane
An alkylating carcinogen that produces gastrointestinal and probably lung and nervous system tumors.
Tracheostomy
Surgical formation of an opening into the trachea through the neck, or the opening so created.
Cerebellar Neoplasms
Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)
PubMed Articles
Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models.
KRAS is one of the most frequently mutated human oncogenes. In some settings, oncogenic KRAS can trigger cellular senescence, whereas in others it produces hyperproliferation. Elucidating the mechanis...
KRAS mutations define a clinically distinct subgroup of lung adenocarcinoma patients, characterized by smoking history, resistance to EGFR-targeted therapies, and adverse prognosis. Whether KRAS-mutat...
NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression.
Mutant KRAS in lung cancers induce molecular pathways that regulate cellular proliferation, survival and inflammation, which enhance tumorigenesis. Inducible nitric oxide synthese (NOS2) up-regulation...
BACKGROUND: Oncogenic gene mutations observed in lung adenocarcinomas, such as epidermal growth factor receptor (EGFR) and KRAS, have some predictive value for chemotherapeutic drugs or EGFR-tyrosine...
Background/Aims: Cetuximab is currently approved for the treatment of metastatic colorectal cancer (mCR) with KRAS wild-type. Prior few studies demonstrated that G13D mutated tumors could benefit from...
Clinical Trials
Regional Lung Opening and Closing Pressures in Patients With Acute Lung Injury
The purpose of this study is the measurement of regional opening and closing pressures of lung tissue by electrical impedance tomography in lung healthy and patients with acute lung injury...
The purpose of this Phase 2 study is to investigate whether intravenous administration of a wild type reovirus (REOLYSIN®) in combination with paclitaxel and carboplatin is effective and...
The purpose of this study is to compare the efficacy of AZD6244 in combination with docetaxel versus docetaxel alone in patients with KRAS mutation positive locally advanced or metastatic...
Panitumumab Combination Study With AMG 102 or AMG 479 in Wild-type KRAS mCRC
This study is a global, multicenter, open-label phase 1b and randomized, double-blinded, 2 part, phase 2 study designed to evaluate the safety and efficacy of AMG 102 or AMG 479 in combina...
This study will assess the efficacy of AUY922, when administered weekly at 70 mg/m2, in adult patients with advanced NSCLC, who have received at least two prior lines of chemotherapy. Pati...
