Intestinal microbiota, pathophysiology and translation to probiotic use in patients with irritable bowel syndrome.
Summary of "Intestinal microbiota, pathophysiology and translation to probiotic use in patients with irritable bowel syndrome."
Probiotic agents have received growing attention in recent years as an alternative therapeutic tool in the management of irritable bowel syndrome. In this article, we will discuss the rationale that support this indication, including the role of intestinal microbiota in gastrointestinal function in both human and animal models, potential links between an impaired microbiota imbalance and the psycho-immunopathophysiology of irritable bowel syndrome, and the results of the available clinical trials to date.
Affiliation
Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Jacksonville, FL, USA.
Journal Details
This article was published in the following journal.
Name: Expert review of gastroenterology & hepatology
ISSN: 1747-4132
Pages: 383-98
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22646259
- DOI: http://dx.doi.org/10.1586/egh.12.9
Medical and Biotech [MESH] Definitions
Ileus
A condition caused by the lack of intestinal PERISTALSIS or INTESTINAL MOTILITY without any mechanical obstruction. This interference of the flow of INTESTINAL CONTENTS often leads to INTESTINAL OBSTRUCTION. Ileus may be classified into postoperative, inflammatory, metabolic, neurogenic, and drug-induced.
Lymphangiectasis, Intestinal
Dilatation of the intestinal lymphatic system usually caused by an obstruction in the intestinal wall. It may be congenital or acquired and is characterized by DIARRHEA; HYPOPROTEINEMIA; peripheral and/or abdominal EDEMA; and PROTEIN-LOSING ENTEROPATHIES.
Irritable Mood
Abnormal or excessive excitability with easily triggered anger, annoyance, or impatience.
Regulatory Sequences, Ribonucleic Acid
Sequences within RNA that regulate the processing, stability (RNA STABILITY) or translation (TRANSLATION, GENETIC) of RNA.
Codon, Initiator
A codon that directs initiation of protein translation (TRANSLATION, GENETIC) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon.
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