A multiscale, spatially-distributed model of asthmatic airway hyper-responsiveness.
Summary of "A multiscale, spatially-distributed model of asthmatic airway hyper-responsiveness."
We present a multiscale, spatially-distributed model of lung and airway behaviour with the goal of furthering understanding of airway hyper-responsiveness and asthma. The model provides an initial computational framework for linking events at the cellular and molecular levels, such as Ca(2+) and crossbridge dynamics, to events at the level of the entire organ. At the organ level, parenchymal tissue is modelled using a continuum approach as a compressible, hyperelastic material in three dimensions, with expansion and recoil of lung tissue due to tidal breathing. The governing equations of finite elasticity deformation are solved using a finite element method. The airway tree is embedded in this tissue, where each airway is modelled with its own airway wall, smooth muscle and surrounding parenchyma. The tissue model is then linked to models of the crossbridge mechanics and their control by Ca(2+) dynamics, thus providing a link to molecular and cellular mechanisms in airway smooth muscle cells. By incorporating and coupling the models at these scales, we obtain a detailed, computational multiscale model incorporating important physiological phenomena associated with asthma.
Affiliation
Department of Mathematics, University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand.
Journal Details
This article was published in the following journal.
Name: Journal of theoretical biology
ISSN: 1095-8541
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20678506
- DOI: http://dx.doi.org/10.1016/j.jtbi.2010.07.032
Medical and Biotech [MESH] Definitions
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Hyper-igm Immunodeficiency Syndrome, Type 1
An X-linked hyper-IgM immunodeficiency subtype resulting from mutation in the gene encoding CD40 LIGAND.
Models, Statistical
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
Airway Remodeling
The structural changes in the number, mass, size and/or composition of the airway tissues.
Airway Management
Evaluation, planning, and use of a range of procedures and airway devices for the maintenance or restoration of a patient's ventilation.
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