Biomarkers intersect with the exposome.
Summary of "Biomarkers intersect with the exposome."
The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies. The initial component, referred to as an exposome-wide-association study (EWAS), employs metabolomics and proteomics to interrogate the serum exposome and, ultimately, to identify, validate and differentiate biomarkers of exposure and biomarkers of disease. Follow-up studies employ knowledge-driven designs to explore disease causality, prevention, diagnosis, prognosis and treatment.
Affiliation
Center for Exposure Biology, School of Public Health, University of California , Berkeley, CA , USA.
Journal Details
This article was published in the following journal.
Name: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
ISSN: 1366-5804
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22672124
- DOI: http://dx.doi.org/10.3109/1354750X.2012.691553
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