Prostate-Cancer Mortality after PSA Screening.
Summary of "Prostate-Cancer Mortality after PSA Screening."
To the Editor: In their article, Schröder et al. (March 15 issue)(1) provide an update on the European Randomized Study of Screening for Prostate Cancer (ERSPC) after 11 years of follow-up. Their extended analysis is of great importance given the considerable controversy regarding the benefits, risks, and costs of population-based screening for prostate cancer, as reflected in the lively discussion that followed the release of the draft recommendation against screening by the U.S. Preventive Services Task Force.(2) It is an established principle of evidence-based medicine to base clinical decision making on the entire body of evidence rather than on individual . . .
Affiliation
Journal Details
This article was published in the following journal.
Name: The New England journal of medicine
ISSN: 1533-4406
Pages: 2228-31
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22670917
- DOI: http://dx.doi.org/10.1056/NEJMc1204298#SA4
Medical and Biotech [MESH] Definitions
Prostate-specific Antigen
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
Seer Program
A cancer registry mandated under the National Cancer Act of 1971 to operate and maintain a population-based cancer reporting system, reporting periodically estimates of cancer incidence and mortality in the United States. The Surveillance, Epidemiology, and End Results (SEER) Program is a continuing project of the National Cancer Institute of the National Institutes of Health. Among its goals, in addition to assembling and reporting cancer statistics, are the monitoring of annual cancer incident trends and the promoting of studies designed to identify factors amenable to cancer control interventions. (From National Cancer Institute, NIH Publication No. 91-3074, October 1990)
Fenretinide
A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.
Neonatal Screening
The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.
Ultrasound, High-intensity Focused, Transrectal
Tissue ablation of the PROSTATE performed by ultrasound from a transducer placed in the RECTUM. The procedure is used to treat prostate cancer (PROSTATIC NEOPLASMS) and benign prostatic hypertrophy (PROSTATIC HYPERPLASIA).
PubMed Articles
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Response to the U.S. Preventative Services Task Force Decision on Prostate Cancer Screening.
The population-level data demonstrate that the inception of prostate-specific antigen (PSA) screening has lowered mortality for prostate cancer over the past 2 decades. However, more recent evidence f...
The implementation of screening for prostate cancer.
The objective of this study was to determine whether screening for prostate cancer (PC) reduces PC mortality and, if so, whether the required criteria to be introduced as a population-based screening...
Prostate cancer is the most common cancer and the second leading cause of cancer-related deaths in American men. Although the use of the prostate-specific antigen (PSA) test for prostate cancer screen...
Population screening for prostate cancer: An overview of available studies and meta-analysis.
The objective of the present review was to evaluate the effect of population-based screening on the incidence of prostate cancer, prostate cancer tumor stage and grade, prostate cancer mortality,...
Clinical Trials
Facilitating Shared Decisionmaking About Prostate Cancer Screening
Due to the disputed efficacy of prostate cancer (CaP) screening and treatment, most authorities recommend that providers inform and involve patients in CaP screening decisions.
Dissemination of Prostate Cancer Screening to PCP's in African American Communities
The aims of this project are to adapt and extend the use of academic detailing to the dissemination of prostate cancer (CaP) screening findings to primary care physicians practicing in Afr...
Shared Decision Making: Prostate Cancer Screening
Interventions to Improve Shared Decision-Making: Prostate Cancer Screening is a prospective study of educational interventions to improve the interaction of physicians and their patients a...
There is controversy concerning the preferred treatment for men with localized prostate cancer with regard to the relative effectiveness of different treatments in controlling the cancer a...
Frequency of Prostate-Specific Antigen Screening in African American Men in the San Francisco Area
RATIONALE: Screening may help doctors find prostate cancer sooner, when it may be easier to treat. PURPOSE: This research study is looking at whether patients who are being screened for...
