Physicochemical and microbiological stability studies of extemporaneous antihypertensive pediatric suspensions for hospital use.

09:56 EDT 20th September 2014 | BioPortfolio

Summary of "Physicochemical and microbiological stability studies of extemporaneous antihypertensive pediatric suspensions for hospital use."

Extemporaneous suspensions of the antihypertensive agents furosemide, spironolactone and hydrochlorothiazide for pediatric use have been prepared at University Hospital (Federal University of Santa Catarina - Brazil). The aim of this work was to investigate the physicochemical and microbiological stability of these suspensions over the estimated shelf-life period of seven days and, if necessary, to optimize the formulations by improving the chemical stability. The pediatric suspensions were prepared using drug raw material and were stored at 25 ± 2°C and 5 ± 3°C. Chemical stability was evaluated by HPLC assay of the suspensions for drug content. Physical stability was evaluated by sedimentation volume, redispersibility, particle size, and zeta potential. Viable bacterial and fungal contaminations were assessed according to the official compendium. Furosemide and spironolactone suspensions as prepared herein can be stored for 7 days. However, the hydrochlorothiazide suspension formulation at pH 6.5 demonstrated poor chemical stability and was optimized by adjusting the pH to 3.3 where the drug exhibited acceptable stability. The optimized formulation demonstrated to be stable over the required period of 7 days.


Department of Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Catarina , Quality Control Laboratory, Florianópolis-SC , Brazil.

Journal Details

This article was published in the following journal.

Name: Pharmaceutical development and technology
ISSN: 1097-9867


PubMed Articles [16851 Associated PubMed Articles listed on BioPortfolio]

Microbiological and Genetic Characterization of Carbapenem-Resistant Klebsiella pneumoniae Isolated From Pediatric Patients.

This manuscript reports the clinical, microbiological, and genetic characteristics of carbapenem-resistant K. pnuemoniae isolates from pediatric patients at a tertiary-care children's hospital. Althou...

Sense and nonsense of extemporaneous formulations.

The subject of Dermatology has changed significantly in light of the fast development of new therapeutic strategies. Potent systemic agents are no longer confined to the oncological. Nevertheless, top...

The physicochemical and microbiological characteristics of saliva during and after pregnancy.

Objectives Identify the changes in some physiological and microbiological parameters in the saliva from a group of women during and after their pregnancies. Methods Stimulated whole saliva was collect...

Nanosilver against fungi. Silver nanoparticles as an effective biocidal factor.

The work presents a method of obtaining an aqueous raspberry extract as well as its physicochemical and analytical characteristics. The paper also contains a description of the method of preparation o...

Quality and storability of chicken nuggets formulated with green banana and soybean hulls flours.

The present study was envisaged to investigate the effect of green banana (GBF) and soybean hulls flours (SHF) on the physicochemical characteristics, colour, texture and storage stability of chicken ...

Clinical Trials [1767 Associated Clinical Trials listed on BioPortfolio]

Effect of Fenofibrate on Endothelial Function and High-density Lipoproteins (HDL) Physicochemical and Functional Characteristics in Patients With Coronary Heart Disease

Fenofibrate is a drug that acts on the PPAR alpha receptors, increasing HDL-cholesterol and decreasing triglyceride levels. The interaction with these receptors has antiatherogenic actions...

TMC114-TiDP29-C232 - Study Providing Continued Access to Treatment With Darunavir (DRV)/Ritonavir (Rtv) for Children Coming From Any of the Three Ongoing Tibotec Sponsored Pediatric Studies With DRV

The primary objective of this study is to continue to provide Darunavir (DRV) to pediatric patients who previously received DRV in any of three pediatric clinical studies sponsored by Tibo...

Clinical and Microbiological Effects of a Mouthwash Containing Chlorine Dioxide

Previous research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (ClO2). However, no clinical studies have investigated its microbiological efficacie...

Gait Stability of People With Lower-Limb Amputations

The purpose of this study is to evaluate whether there are quantifiable differences in walking stability, as measured by the acceleration of the trunk or the variation in step length, betw...

Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives

To study the effect of sibutramine treatment on weight reduction and blood pressure improvement in three groups with antihypertensive therapy whose blood pressure was not adequately contro...

Medical and Biotech [MESH] Definitions

Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.

Studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. The common types of analytic study are CASE-CONTROL STUDIES; COHORT STUDIES; and CROSS-SECTIONAL STUDIES.

Sequences within RNA that regulate the processing, stability (RNA STABILITY) or translation (TRANSLATION, GENETIC) of RNA.

Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.

Physical reactions involved in the formation of or changes in the structure of atoms and molecules and their interactions.

Search BioPortfolio:

Relevant Topic

Latest News Clinical Trials Research Drugs Reports Corporate
Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...