Pediatric Hashimoto encephalopathy, refractory epilepsy, and immunoglobulin treatment - unusual case report and review of the literature.
Summary of "Pediatric Hashimoto encephalopathy, refractory epilepsy, and immunoglobulin treatment - unusual case report and review of the literature."
Abstract Background: Hashimoto encephalopathy is a rare autoimmune disorder. It is defined as a "corticosteroid-responsive encephalopathy associated with thyroiditis" Clinical observation: We describe a boy who suffered from Hashimoto encephalopathy, responded only to intravenous immunoglobulin therapy. This is the first case report of immunoglobulin therapy in pediatric Hashimoto encephalopathy. Conclusion: After review of the literature, we recommend that unexplained encephalopathy in children should lead to evaluation of thyroid autoantibody titers. Immunoglobulins should be considered.
Affiliation
. The Neuro-Pediatric Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Journal Details
This article was published in the following journal.
Name: Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20678162
- DOI: http://dx.doi.org/10.1111/j.1651-2227.2010.01967.x
Medical and Biotech [MESH] Definitions
Vagus Nerve Stimulation
An adjunctive treatment for PARTIAL EPILEPSY and refractory DEPRESSION that delivers electrical impulses to the brain via the VAGUS NERVE. A battery implanted under the skin supplies the energy.
Immunoglobulins, Intravenous
Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.
Immunoglobulin J-chains
A 15 kD "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains.
Anemia, Refractory, With Excess Of Blasts
Chronic refractory anemia with granulocytopenia, and/or thrombocytopenia. Myeloblasts and progranulocytes constitute 5 to 40 percent of the nucleated marrow cells.
Immunoglobulin Epsilon-chains
The class of heavy chains found in IMMUNOGLOBULIN E. They have a molecular weight of approximately 72 kDa and they contain about 550 amino acid residues arranged in five domains and about three times more carbohydrate than the heavy chains of IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; and IMMUNOGLOBULIN G.
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